Evidence map›Paper›PMID 33429295›Full record

ArticleDrug and alcohol dependence2021

The relationship of smoking and unhealthy alcohol use to the HIV care continuum among people with HIV in an integrated health care system.

Derek D Satre, Tory Levine-Hall, Stacy A Sterling, Kelly C Young-Wolff, Jennifer O Lam, Stacey Alexeeff, J Carlo Hojilla, Andrew Williams, Amy C Justice, Jonathan Sterne and 7 more

Abstract read
In one paragraph

Article in Drug and alcohol dependence, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Trial
  2. Article
  3. The role of alternative reinforcers in smoking outcomes among people with and without HIV.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2025
    Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Derek D SatreDepartment of Psychiatry and Behavioral Sciences, Weill Institute for Neurosciences, University of California, San Francisco, CA, USA; Kaiser Permanente Northern California, Oakland, CA, USA. Electronic address: derek.satre@ucsf.edu.
Tory Levine-HallKaiser Permanente Northern California, Oakland, CA, USA.
Stacy A SterlingKaiser Permanente Northern California, Oakland, CA, USA.
Kelly C Young-WolffDepartment of Psychiatry and Behavioral Sciences, Weill Institute for Neurosciences, University of California, San Francisco, CA, USA; Kaiser Permanente Northern California, Oakland, CA, USA.
Jennifer O LamKaiser Permanente Northern California, Oakland, CA, USA.
Stacey AlexeeffKaiser Permanente Northern California, Oakland, CA, USA.
J Carlo HojillaKaiser Permanente Northern California, Oakland, CA, USA.
Andrew WilliamsTufts Medical Center, Boston, MA, USA.
Amy C JusticeYale University, New Haven, CT, USA.
Jonathan SterneUniversity of Bristol, Bristol, UK.
Matthias CavassiniLausanne University Hospital, Lausanne, Switzerland.
Kendall J BryantNational Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, USA.
Emily C WilliamsHealth Services Research & Development (HSR&D), Center of Innovation for Veteran-Centered Value-Driven Care, Veteran Affairs (VA) Puget Sound Health Care System, Seattle, WA, USA; Department of Health Services, University of Washington, Seattle, WA, USA.
Michael A HorbergMid-Atlantic Permanente Research Institute, Kaiser Permanente Mid-Atlantic States, Rockville, MD, USA.
Paul VolberdingAIDS Research Institute, University of California, San Francisco, USA.
Constance WeisnerDepartment of Psychiatry and Behavioral Sciences, Weill Institute for Neurosciences, University of California, San Francisco, CA, USA; Kaiser Permanente Northern California, Oakland, CA, USA.
Michael J SilverbergKaiser Permanente Northern California, Oakland, CA, USA.

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Virology CoreP30AI027763 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STEVEN Grant DEEKS · 1988 to 2026
$93.6M
Tufts Clinical and Translational Science Institute (Pilot Supplement)UL1TR002544 · NCATS · TUFTS UNIVERSITY BOSTON · PI SELKER, HARRY P. · 2018 to 2022
$50.2M
Substance Use Disorders Treatment/Services Research Training ProgramT32DA007250 · NIDA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Derek D Satre, Janice Y Tsoh · 1991 to 2026
$7.4M
2/3 COMpAAAS Tripartite: ART-CC, KP, and VAU01AA026230 · NIAAA · KAISER FOUNDATION RESEARCH INSTITUTE · PI SATRE, DEREK D, SILVERBERG, MICHAEL J · 2017 to 2021
$3.0M
1/3 Collaborative Research in HIV/AIDS, Alcohol, and Related Comorbidities (COMpAAAS) Tripartite: ART-CC, KP, and VAU01AA026209 · NIAAA · UNIVERSITY OF BRISTOL · PI STERNE, JONATHAN · 2017 to 2021
$2.2M
Mentoring alcohol use intervention research in HIV health care settingsK24AA025703 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Derek D Satre · 2018 to 2026
$1.8M
Population-based Screening and Brief Intervention in Primary Care: Health and Drinking Outcomes, Cost and UtilizationR01AA025902 · NIAAA · KAISER FOUNDATION RESEARCH INSTITUTE · PI STERLING, STACY ANN · 2017 to 2020
$1.6M
Medical Research Council G0100221Medical Research Council G0700820Medical Research Council MR/J002380/1NCATS NIH HHS UL1 TR001863NCATS NIH HHS UL1 TR002544NIAAA NIH HHS K24 AA025703NIAAA NIH HHS R01 AA025902NIAAA NIH HHS U01 AA026209NIAAA NIH HHS U01 AA026230NIAID NIH HHS P30 AI027763NIDA NIH HHS T32 DA007250
6 · The paper itself

Abstract

introductionSmoking tobacco and unhealthy alcohol use may negatively influence HIV care continuum outcomes but have not been examined in combination.

methodsParticipants were people with HIV (PWH) in Kaiser Permanente Northern California. Predictors included smoking status and unhealthy alcohol use (exceeding daily and/or weekly limits) reported by patients during primary care screening (index date). Outcomes were based on not achieving the following steps in the care continuum: linkage to HIV care (≥1 visit within 90 days of newly identified HIV diagnosis), retention (2+ in-person visits, 60+ days apart) and HIV RNA control (<75 copies/mL). Adjusted odds ratios (ORs) were obtained from separate logistic regression models for each outcome associated with smoking and unhealthy alcohol use independently and combined.

resultsThe overall sample (N = 8958) had a mean age of 48.0 years; was 91.3 % male; 54.0 % white, 17.6 % Latino, 15.1 % black, and 9.6 % other race/ethnicity. Smoking was associated with higher odds of not being linked to HIV care (OR = 1.60 [95 % CI 1.03-2.48]), not retained (OR = 1.30 [95 % CI 1.13-1.50]), and HIV RNA not in control (OR = 1.91 [95 % CI 1.60-2.27]). Alcohol measures were not independently associated with outcomes. The combination of unhealthy alcohol use and smoking (versus neither) was associated with higher odds of not being linked to care (OR = 2.83 [95 % CI 1.40-5.71]), although the interaction did not reach significance (p = 0.18).

conclusionsIn this large sample of PWH in an integrated health care system, smoking, both independently and in combination with unhealthy alcohol use, was associated with worse HIV care continuum outcomes.

Indexed as

AdultAlcohol DrinkingContinuity of Patient CareDelivery of Health Care, IntegratedFemaleHIV InfectionsHumansMaleMiddle AgedPrimary Health CareSmokingTobacco SmokingAlcoholHIV care continuumIntegrated health carePrimary careSmokingViral control

Identifiers

PMID33429295
PMCPMC7869693

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.