Evidence map›Paper›PMID 33429022›Full record

ArticleFree radical biology & medicine2021

Role of necroptosis in chronic hepatic inflammation and fibrosis in a mouse model of increased oxidative stress.

Sabira Mohammed, Evan H Nicklas, Nidheesh Thadathil, Ramasamy Selvarani, Gordon H Royce, Michael Kinter, Arlan Richardson, Sathyaseelan S Deepa

Open access · hybridAbstract read
In one paragraph

Article in Free radical biology & medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed, 1 pooled it
14.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 1 synthesis or guideline pooled it, 112 citations in OpenAlex.

  1. Pooled it
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  15. Transcriptomic analysis of Paraoxonase 1 expression in hepatocellular carcinoma and its potential impact on tumor immunity.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025
    Article
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  18. Microcystin-LR activates serine/threonine kinases and alters the phosphoproteome in human HepaRG cells.Toxicon : official journal of the International Society on Toxinology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Sabira MohammedStephenson Cancer Center, USA.
Evan H NicklasDepartment of Biochemistry and Molecular Biology, USA.
Nidheesh ThadathilDepartment of Biochemistry and Molecular Biology, USA.
Ramasamy SelvaraniDepartment of Biochemistry and Molecular Biology, USA.
Gordon H RoyceDepartment of Biochemistry and Molecular Biology, USA.
Michael KinterAging and Metabolism Research Program, Oklahoma Medical Research Foundation, USA.
Arlan RichardsonStephenson Cancer Center, USA; Department of Biochemistry and Molecular Biology, USA; Oklahoma Center for Geroscience & Brain Aging, University of Oklahoma Health Sciences Center, USA; Oklahoma City VA Medical Center, Oklahoma City, OK, USA.
Sathyaseelan S DeepaStephenson Cancer Center, USA; Department of Biochemistry and Molecular Biology, USA; Oklahoma Center for Geroscience & Brain Aging, University of Oklahoma Health Sciences Center, USA. Electronic address: Deepa-Sathyaseelan@ouhsc.edu.
Molecular Biology Consortium · USOklahoma City VA Medical Center · USOklahoma Medical Research Foundation · USOU Health Stephenson Cancer Center

Funding

Targeted DNA Methylation and Mitochondrial Heteroplasmy CoreP30AG050911 · NIA · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI Matthew John Hart · 2015 to 2026
$13.9M
The Role of Necroptosis in AgingR01AG059718 · NIA · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI Deepa Sathyaseelan · 2019 to 2026
$3.0M
TESTING THE ABILITY OF NOVEL ASSAYS OF RESILIENCE TO PREDICT LIFESPANR01AG057424 · NIA · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI RICHARDSON, ARLAN G., SONNTAG, WILLIAM EDMUND · 2017 to 2021
$2.0M
Effect of Necroptosis in Neurons on Neuroinflammation, Neuronal Function, and CognitionI01BX004538 · VA · OKLAHOMA CITY VA MEDICAL CENTER · PI FREEMAN, WILLARD M, RICHARDSON, ARLAN G. · 2019 to 2024
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BLRD VA I01 BX004538BLRD VA IK6 BX005238NIA NIH HHS P30 AG050911NIA NIH HHS R01 AG057424NIA NIH HHS R01 AG059718
6 · The paper itself

Abstract

Mice deficient in the antioxidant enzyme Cu/Zn-superoxide dismutase (Sod1

Indexed as

Carcinoma, HepatocellularLiver NeoplasmsNon-alcoholic Fatty Liver DiseaseAnimalsDisease Models, AnimalFibrosisInflammationLiverMiceMice, Inbred C57BLNecroptosisOxidative StressAutophagyCu/Zn superoxide dismutaseFibrosisHepatocellular carcinomaInflammationNecroptosisNecrostatin-1sNon-alcoholic fatty liver diseaseNon-alcoholic hepatosteatosisOxidative stress

Identifiers

PMID33429022
PMCPMC8845573
OpenAlexW3118331092

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.