ArticlePloS one2021
CYP450 core involvement in multiple resistance strains of Aedes aegypti from French Guiana highlighted by proteomics, molecular and biochemical studies.
Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 36 citations in OpenAlex.
- Single-cell transcriptional landscapes of Aedes aegypti midgut and fat body after a bloodmeal.Cell genomics · 2025Article
- Deltamethrin Selection Drives Transcriptomic Changes in Detoxification, Immune, and Cuticle Genes inTropical medicine and infectious disease · 2025Article
- Characterization of the transcriptional cellular response in midgut tissue of temephos-resistant Aedes aegypti larvae.Parasites & vectors · 2025Article
- Article
- Assessing pyrethroid resistance in Aedes aegypti from Cordoba Colombia: Implications of kdr mutations.PloS one · 2024Article
- Article
- Potential of MALDI-TOF MS biotyping to detect deltamethrin resistance in the dengue vector Aedes aegypti.PloS one · 2024Article
- Time-series analysis of transcriptomic changes due to permethrin exposure reveals that Aedes aegypti undergoes detoxification metabolism over 24 h.Scientific reports · 2023Article
- Viral Prevalence and Genomic Xenology in the Coevolution of HzNV-2 (Nudiviridae) with HostInsects · 2023Article
- Quantitative proteomics analysis of permethrin and temephos-resistant Ae. aegypti revealed diverse differentially expressed proteins associated with insecticide resistance from Penang Island, Malaysia.PLoS neglected tropical diseases · 2023Article
- Article
- Enrichment of phenotype among biological forms of Anopheles stephensi Liston through establishment of isofemale lines.Parasites & vectors · 2023Article
- Impact of CHIKV Replication on the Global Proteome ofProteomes · 2022Article
- Deletion of Constitutive Androstane Receptor Led to Intestinal Alterations and Increased Imidacloprid in Murine Liver.Journal of the Endocrine Society · 2022Article
- BioRssay: an R package for analyses of bioassays and probit graphs.Parasites & vectors · 2022Article
- Evaluation of Total Female and MaleInsects · 2021Article
- Gradual reduction of susceptibility and enhanced detoxifying enzyme activities of laboratory-rearedToxicology reports · 2021Article
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Authors and funding
11 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Insecticide resistance is a worldwide threat for vector control around the world, and Aedes aegypti, the main vector of several arboviruses, is a particular concern. To better understand the mechanisms of resistance, four isofemale strains originally from French Guiana were isolated and analysed using combined approaches. The activity of detoxification enzymes involved in insecticide resistance was assayed, and mutations located at positions 1016 and 1534 of the sodium voltage-gated channel gene, which have been associated with pyrethroid resistance in Aedes aegypti populations in Latin America, were monitored. Resistance to other insecticide families (organophosphates and carbamates) was evaluated. A large-scale proteomic analysis was performed to identify proteins involved in insecticide resistance. Our results revealed a metabolic resistance and resistance associated with a mutation of the sodium voltage-gated channel gene at position 1016. Metabolic resistance was mediated through an increase of esterase activity in most strains but also through the shifts in the abundance of several cytochrome P450 (CYP450s). Overall, resistance to deltamethrin was linked in the isofemale strains to resistance to other class of insecticides, suggesting that cross- and multiple resistance occur through selection of mechanisms of metabolic resistance. These results give some insights into resistance to deltamethrin and into multiple resistance phenomena in populations of Ae. aegypti.
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