SynthesisPloS one2021
Pharmacologic interventions for postoperative nausea and vomiting after thyroidectomy: A systematic review and network meta-analysis.
Synthesis in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.
- Efficacy and Safety of Ketamine-Dexmedetomidine Versus Ketamine-Propofol Combination for Periprocedural Sedation: A Systematic Review and Meta-analysis.Current pain and headache reports · 2024Pooled it
- Efficacy and safety of perioperative intravenous dexamethasone in type 2 diabetes mellitus patients undergoing total hip arthroplasty: a prospective randomized controlled trial.Journal of orthopaedic surgery and research · 2026Trial
- Development and Validation of a Dynamic Nomogram for Predicting Postdischarge Nausea and Vomiting in Adults Undergoing Ambulatory Surgery: A Retrospective Cohort Study.International journal of nursing practice · 2026Article
- Prevalence and factors associated with postoperative nausea and vomiting in Ethiopia: a systematic review and meta-analysis.Annals of medicine and surgery (2012) · 2026Article
- Post-Thyroidectomy Nausea and Vomiting Using Continuous Remifentanil Infusion During Emergence Depending on the Inhaled Anesthetics: A Retrospective Cohort Study.Medicina (Kaunas, Lithuania) · 2026Article
- Recent progress in postoperative nausea and vomiting after thyroidectomy.Frontiers in surgery · 2026Review
- Continuum-based postoperative nausea and vomiting prophylaxis protocol: Development and real-world implementation checklist.Indian journal of anaesthesia · 2025Article
- Effect of Prophylactic Tropisetron on Post-Operative Nausea and Vomiting in Patients Undergoing General Anesthesia: Systematic Review and Meta-Analysis with Trial Sequential Analysis.Journal of personalized medicine · 2024Review
- Assessing the validity and reliability of the 10-item Persian version of the perceived stress scale in post-surgery patients.Frontiers in psychiatry · 2024Article
- Postoperative nausea and vomiting in spinal anesthesia.Korean journal of anesthesiology · 2023Article
- Comparison of the Effectiveness of Palonosetron and Ramosetron in Preventing Postoperative Nausea and Vomiting: Updated Systematic Review and Meta-Analysis with Trial Sequential Analysis.Journal of personalized medicine · 2022Review
- Antiemetic Prophylaxis with Ramosetron for Postoperative Nausea and Vomiting in Patients Undergoing Microvascular Decompression : A Prospective, Randomized Controlled Trial.Journal of Korean Neurosurgical Society · 2022Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine the effectiveness of pharmacologic interventions for preventing postoperative nausea and vomiting (PONV) in patients undergoing thyroidectomy.
designSystematic review and network meta-analysis (NMA). DATA SOURCES: MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, and Google Scholar. ELIGIBILITY CRITERIA, PARTICIPANTS, AND
interventionsRandomized clinical trials that investigated the efficacy of pharmacologic interventions in preventing PONV in patients undergoing thyroidectomy were included. The primary endpoints were the incidences of postoperative nausea and vomiting (PONV), postoperative nausea (PON), postoperative vomiting (POV), use of rescue antiemetics, and incidence of complete response in the overall postoperative phases. The secondary endpoints were the same parameters assessed in the early, middle, and late postoperative phases. The surface under the cumulative ranking curve (SUCRA) values and rankograms were used to present the hierarchy of pharmacologic interventions.
resultsTwenty-six studies (n = 3,467 patients) that investigated 17 different pharmacologic interventions were included. According to the SUCRA values, the incidence of PONV among the overall postoperative phases was lowest with propofol alone (16.1%), followed by palonosetron (27.5%), and with tropisetron (28.7%). The incidence of PON among the overall postoperative phases was lowest with propofol alone (11.8%), followed by tropisetron and propofol combination (14%), and ramosetron and dexamethasone combination (18.0%). The incidence of POV among the overall postoperative phases was lowest with tropisetron and propofol combination (2.2%), followed by ramosetron and dexamethasone combination (23.2%), and tropisetron alone (37.3%). The least usage of rescue antiemetics among the overall postoperative phases and the highest complete response was observed with tropisetron and propofol combination (3.9% and 96.6%, respectively).
conclusionPropofol and tropisetron alone and in combination, and the ramosetron and dexamethasone combination effectively prevented PONV, PON, POV in patients undergoing thyroidectomy, with some heterogeneity observed in this NMA of full-text reports. Their use minimized the need for rescue antiemetics and enhanced the complete response. TRIAL REGISTRATION NUMBER: CRD42018100002.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.