ArticlePloS one2021
Isolation and characterization of lumpy skin disease virus from cattle in India.
Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
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59 citing papers in PubMed, 134 citations in OpenAlex.
- First molecular and phylogenetic study of the bovine lumpy skin disease virus declared in Algeria in 2024.Archives of virology · 2026Article
- Molecular detection and isolation of Lumpy Skin Disease Virus from outbreak cases in Ilubabor Zone, Oromia, Ethiopia.BMC microbiology · 2026Article
- Comparison of whole genome sequencing approaches for Capripox viruses.BMC genomics · 2026Article
- Research Review on Inhibitors of Lumpy Skin Disease Virus: From Biological Characteristics, Drug Repurposing, to Computer-Aided Drug Design.International journal of microbiology · 2026Review
- Review
- Development and evaluation of an experimental inactivated vaccine against lumpy skin disease.Veterinary world · 2025Article
- Lumpy Skin Disease Virus (LSDV): evaluating global impact, Ethiopia's response strategies, and the promise of gamma-ray inactivated vaccines.Tropical animal health and production · 2025Review
- Comprehensive Evaluation of the Immune Response of Angus Cattle to Live Attenuated and Inactivated Goatpox Virus Vaccines.Animals : an open access journal from MDPI · 2025Article
- Molecular detection and phylogenetic analysis of lumpy skin disease virus in Yunnan Province, China from 2019 to 2023.Veterinary research communications · 2025Article
- Improving Cattle Health and Welfare in the Area Affected by the First Outbreak of Lumpy Skin Disease in Indonesia.Veterinary sciences · 2025Article
- Investigation of the Pathogenesis of Lumpy Skin Disease Virus in Indigenous Cattle in Kazakhstan.Pathogens (Basel, Switzerland) · 2025Article
- Establishment of an indirect ELISA antibody detection method based on the stable expression of LSDV P32 protein in CHO-K1 cells.BMC biotechnology · 2025Article
- Epidemiology of lumpy skin disease in Northeast India and a new method for rapid field diagnosis.AMB Express · 2025Article
- Assessment of economic burden of lumpy skin disease in India using stochastic modeling.Scientific reports · 2025Article
- Mathematical model of the lumpy skin disease using Caputo fractional-order derivative via invariant point technique.Scientific reports · 2025Article
- Molecular Detection, Seroprevalence and Biochemical Analysis of Lumpy Skin Disease Virus.Viruses · 2025Article
- Lumpy skin disease: A growing threat to the global livestock industry.Open veterinary journal · 2025Review
- Effects of quarantine and vaccination on the transmission of Lumpy skin disease: A fractional approach.PloS one · 2025Article
- Detection and variant characterization of lumpy skin disease virus from dairy cattle in India.Virus evolution · 2025Article
- Evidence of natural lumpy skin disease virus (LSDV) infection and genetic characterization of LSDV strains from water buffaloes (Bubalus bubalis) in India.Archives of virology · 2024Article
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lumpy skin disease (LSD) has devastating economic impact. During the last decade, LSD had spread to climatically new and previously disease-free countries, which also includes its recent emergence in the Indian subcontinent (2019). This study deals with the LSD outbreak(s) from cattle in Ranchi (India). Virus was isolated from the scabs (skin lesions) in the primary goat kidney cells. Phylogenetic analysis based on nucleotide sequencing of LSD virus (LSDV) ORF011, ORF012 and ORF036 suggested that the isolated virus (LSDV/Bos taurus-tc/India/2019/Ranchi) is closely related to Kenyan LSDV strains. Further, we adapted the isolated virus in Vero cells. Infection of the isolated LSDV to Vero cells did not produce cytopathic effect (CPE) until the 4th blind passage, but upon adaptation, it produced high viral titres in the cultured cells. The kinetics of viral DNA synthesis and one-step growth curve analysis suggested that Vero cell-adapted LSDV initiates synthesizing its genome at ~24 hours post-infection (hpi) with a peak level at ~96 hpi whereas evidence of progeny virus particles was observed at 36-48 hours (h) with a peak titre at ~120 h. To the best of our knowledge, this study describes the first successful isolation of LSDV in India, besides providing insights into the life cycle Vero cell-adapted LSDV.
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