ArticlePLoS genetics2021
Population structure of indigenous inhabitants of Arabia.
Article in PLoS genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Genetic variation of 15 autosomal STR loci in the southern region population of KSA: A forensic DNA analysis study.Journal of Taibah University Medical Sciences · 2026Article
- Adaptive admixture at ACKR1, the Duffy blood group locus, may have shaped Plasmodium vivax prevalence in Oman.American journal of human genetics · 2026Article
- Genetic profile of Charcot-Marie-Tooth disease in the Saudi population: A retrospective study highlighting the role of consanguinity.Neurosciences (Riyadh, Saudi Arabia) · 2025Article
- Near-complete Middle Eastern genomes refine autozygosity and enhance disease-causing and population-specific variant discovery.Nature genetics · 2025Article
- Validity of the Arabic version of AAOS-foot and ankle outcomes questionnaire in patients with traumatic foot and ankle injuries.World journal of orthopedics · 2025Article
- Patterns of population structure and genetic variation within the Saudi Arabian population.bioRxiv : the preprint server for biology · 2025Article
- A reference quality, fully annotated diploid genome from a Saudi individual.Scientific data · 2024Article
- The impact of consanguinity on the design of iPSC banks.Stem cell reports · 2024Article
- Founder mutations and rare disease in the Arab world.Disease models & mechanisms · 2024Review
- Imputation accuracy across global human populations.American journal of human genetics · 2024Article
- Pragmatic Approach to Applying Polygenic Risk Scores to Diverse Populations.Current protocols · 2023Article
- Imputation Accuracy Across Global Human Populations.bioRxiv : the preprint server for biology · 2023Article
- Clinical utility of polygenic scores for cardiometabolic disease in Arabs.Nature communications · 2023Article
- A transcriptomic signature of X chromosome overdosage in Saudi Klinefelter syndrome induced pluripotent stem cells.Endocrine connections · 2023Article
- Portability of Polygenic Risk Scores for Sleep Duration, Insomnia and Chronotype in 33,493 Individuals.Clocks & sleep · 2022Article
- Epidemiological determinants for the spread of COVID-19 in Riyadh Province of Saudi Arabia.Saudi journal of biological sciences · 2022Article
- Article
- Thousands of Qatari genomes inform human migration history and improve imputation of Arab haplotypes.Nature communications · 2021Article
- Familial thrombocythaemia - a distinct entity from essential thrombocythaemia.British journal of haematology · 2021Article
- Indigenous Arabs have an intermediate frequency of a Neanderthal-derived COVID-19 risk haplotype compared with other world populations.Clinical genetics · 2021Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Modern day Saudi Arabia occupies the majority of historical Arabia, which may have contributed to ancient waves of migration out of Africa. This ancient history has left a lasting imprint in the genetics of the region, including the diverse set of tribes that call Saudi Arabia their home. How these tribes relate to each other and to the world's major populations remains an unanswered question. In an attempt to improve our understanding of the population structure of Saudi Arabia, we conducted genomic profiling of 957 unrelated individuals who self-identify with 28 large tribes in Saudi Arabia. Consistent with the tradition of intra-tribal unions, the subjects showed strong clustering along tribal lines with the distance between clusters correlating with their geographical proximities in Arabia. However, these individuals form a unique cluster when compared to the world's major populations. The ancient origin of these tribal affiliations is supported by analyses that revealed little evidence of ancestral origin from within the 28 tribes. Our results disclose a granular map of population structure and have important implications for future genetic studies into Mendelian and common diseases in the region.
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