ArticlePLoS genetics2021
Temperature regulates synaptic subcellular specificity mediated by inhibitory glutamate signaling.
Article in PLoS genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 14 citations in OpenAlex.
- Chromosome-level genome assembly and population genomic analysis provide insights into the genetic diversity and adaption of Schizopygopsis younghusbandi on the Tibetan Plateau.Integrative zoology · 2025Article
- O-GlcNAc transferase promotes synaptic assembly independent of catalytic activity inJournal of biosciences · 2025Article
- Regulation Mechanisms of the Glutamate Transporter in the Response of Pacific Oyster upon High-Temperature Stress.International journal of molecular sciences · 2024Article
- Cellular and Molecular Mechanisms Underlying Synaptic Subcellular Specificity.Brain sciences · 2024Review
- The diverse family of Cys-loop receptors inBiophysical reviews · 2023Review
- Gut neuroendocrine signaling regulates synaptic assembly in C. elegans.EMBO reports · 2022Article
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Environmental factors such as temperature affect neuronal activity and development. However, it remains unknown whether and how they affect synaptic subcellular specificity. Here, using the nematode Caenorhabditis elegans AIY interneurons as a model, we found that high cultivation temperature robustly induces defects in synaptic subcellular specificity through glutamatergic neurotransmission. Furthermore, we determined that the functional glutamate is mainly released by the ASH sensory neurons and sensed by two conserved inhibitory glutamate-gated chloride channels GLC-3 and GLC-4 in AIY. Our work not only presents a novel neurotransmission-dependent mechanism underlying the synaptic subcellular specificity, but also provides a potential mechanistic insight into high-temperature-induced neurological defects.
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Registered trials
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