Evidence map›Paper›PMID 33428166›Full record

ArticleInternational urology and nephrology2021

Hypokalemia in peritoneal dialysis patients in Thailand: the pivotal role of low potassium intake.

Mathurot Virojanawat, Pongpratch Puapatanakul, Piyatida Chuengsaman, Chanchana Boonyakrai, Sompon Buranaosot, Pisut Katavetin, Kearkiat Praditpornsilpa, Somchai Eiam-Ong, Talerngsak Kanjanabuch

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Article in International urology and nephrology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Mathurot VirojanawatDivision of Nephrology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Thailand.
Pongpratch PuapatanakulDivision of Nephrology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Thailand.
Piyatida ChuengsamanBanphaeo Dialysis Group (Bangkok), Banphaeo Hospital, Bangkok, Thailand.
Chanchana BoonyakraiDivision of Nephrology, Department of Medicine, Taksin Hospital, Bangkok, Thailand.
Sompon BuranaosotBangkok Metropolitan Administration General Hospital, Bangkok, Thailand.
Pisut KatavetinDivision of Nephrology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Thailand.
Kearkiat PraditpornsilpaDivision of Nephrology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Thailand.
Somchai Eiam-OngDivision of Nephrology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Thailand.
Talerngsak KanjanabuchDivision of Nephrology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Thailand. golfnephro@hotmail.com.ORCID http://orcid.org/0000-0002-2996-8934
Chulalongkorn University · THBangkok Hospital · THBangkok Metropolitan Administration · TH

Funding

National Research Council of Thailand 156/2560Rachadaphiseksompot Endorsement Fund, Chulalongkorn University CU-GRS_60_12_30_05Rachadaphiseksompot Fund, Faculty of Medicine RA61/084Thailand Research Foundation IRG5780017
6 · The paper itself

Abstract

objectiveHypokalemia is highly prevalent in chronic peritoneal dialysis (PD) patients worldwide, particularly in Thailand. This study aims to investigate the major determinants of hypokalemia in Thai PD patients.

methodsA cross-sectional study was performed in chronic PD patients at 4 PD centers in Bangkok, Thailand. Hypokalemia was defined if the average serum potassium level during the last 3 consecutive visits was < 3.5 mEq/L. Patients and/or their caregivers were asked to perform a 3-day dietary food record and take pre- and post-meal pictures following the instructed protocol. Daily dietary nutrients, including potassium, were estimated by a single dietician using INMUCAL-N software. Total potassium excretion was determined by 24-h PD effluents and urine collection. Intracellular and extracellular water values (ICW and ECW, respectively) were measured by electrical bioimpedance assay (BIA) to indirectly explore the role of intracellular potassium shift in hypokalemia.

resultsAmong 60 eligible PD patients, 19 (31%) had hypokalemia. Hypokalemic patients had significantly lower dietary potassium intake (24.4 ± 11.1 vs. 30.5 ± 9.4 mEq/day, p = 0.031) and lower total potassium excretion (28.5 ± 8.4 vs. 36.7 ± 11.2 mEq/day, p = 0.006) compared to normokalemic patients. Both groups had comparable values of ICW and ECW. On logistic regression, there was no significant correlation between hypokalemia and daily PD exchange volume, total Kt/Vurea, residual renal function, concurrent medications (insulin, diuretics, renin-angiotensin-aldosterone inhibitor, and beta-blockers) or ICW. Low dietary potassium was an independent risk factor for hypokalemia.

conclusionLow dietary potassium intake, rather than increased potassium excretion or intracellular shift, is the major contributing factor of hypokalemia in Thai chronic PD patients. Dietary intervention or potassium supplement protocol should be implemented.

Indexed as

Peritoneal DialysisAdultAgedCross-Sectional StudiesFemaleHumansHypokalemiaMaleMiddle AgedPotassium, DietaryThailandPotassium, DietaryDietary potassiumFood recordHypokalemiaPeritoneal dialysis

Identifiers

PMID33428166
OpenAlexW3120774103

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.