Evidence map›Paper›PMID 33428135›Full record

ArticleCurrent medical science2020

Promising Effects of Zerumbone on the Regulation of Tumor-promoting Cytokines Induced by TNF-α-activated Fibroblasts.

Zahra Radaei, Alireza Zamani, Rezvan Najafi, Massoud Saidijam, Farid Azizi Jalilian, Razieh Ezati, Ghasem Solgi, Razieh Amini

Abstract read
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Article in Current medical science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Zahra RadaeiDepartment of Immunology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, 65178, Iran.
Alireza ZamaniDepartment of Immunology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, 65178, Iran.
Rezvan NajafiResearch Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, 65178, Iran.
Massoud SaidijamResearch Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, 65178, Iran.
Farid Azizi JalilianDepartment of Microbiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, 65178, Iran.
Razieh EzatiInstitute of Medical Biotechnology, National Institute of Genetic Engineering and Biotechnology, Tehran, 14965, Iran.
Ghasem SolgiDepartment of Immunology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, 65178, Iran.
Razieh AminiResearch Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, 65178, Iran. aminra14@gmail.com.
Hamedan University of Medical Sciences · IRNational Institute of Genetic Engineering and Biotechnology · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inflammation plays an important role in the development of several cancers. Inflammatory cytokines, including tumor necrosis factor-α (TNF-α), are associated with the induction of inflammation. Chronic inflammation contributes to the progression of cancer through several mechanisms, including increased cytokine production and activation of transcription factors, such as nuclear factor-κB (NF-κB). Zerumbone (ZER), a component of subtropical ginger (Zingiber zerumbet Smith), seems to have anti-inflammatory, anti-cancer, and antioxidant activities. In this study, we aimed to explore the protective function and mechanisms of ZER against TNF-α-induced cancer-promoting cytokines. We found that the viability of stimulated human fibroblast cell lines was reduced after treatment with ZER (IC

Indexed as

Anti-Inflammatory AgentsCell Culture TechniquesCell LineCell SurvivalChemokine CCL2Chemokine CXCL12Culture Media, ConditionedCytokinesFibroblastsGene Expression Regulation, NeoplasticHCT116 CellsHumansInterleukin-33NF-kappa BSesquiterpenesTransforming Growth Factor betaAnti-Inflammatory AgentsCCL2 protein, humanChemokine CCL2Chemokine CXCL12Culture Media, ConditionedCXCL12 protein, humanCytokinesIL33 protein, humanInterleukin-33NF-kappa BSesquiterpenesTransforming Growth Factor betaTumor Necrosis Factor-alphazerumboneactivated fibroblastsinflammationnuclear factor-αB (NF-αB)tumor necrosis factor-α (TNF-α)zerumbone

Identifiers

PMID33428135
OpenAlexW3118345560

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.