Evidence map›Paper›PMID 33428036›Full record

ArticleDigestive diseases and sciences2021

Regional Gastrointestinal Transit and Contractility Patterns Vary in Postural Orthostatic Tachycardia Syndrome (POTS).

Wendy Zhou, Thomas A Zikos, John O Clarke, Linda A Nguyen, George Triadafilopoulos, Leila Neshatian

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Article in Digestive diseases and sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Screening for acute hepatic porphyria in postural tachycardia syndrome.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Wendy ZhouDepartment of Medicine, Santa Clara Valley Medical Center, San Jose, USA.
Thomas A ZikosDivision of Gastroenterology and Hepatology, Stanford University School of Medicine, 430 Broadway St, Pav C 3rd Floor, GI Suite, Redwood City, CA, 94063, USA.
John O ClarkeDivision of Gastroenterology and Hepatology, Stanford University School of Medicine, 430 Broadway St, Pav C 3rd Floor, GI Suite, Redwood City, CA, 94063, USA.
Linda A NguyenDivision of Gastroenterology and Hepatology, Stanford University School of Medicine, 430 Broadway St, Pav C 3rd Floor, GI Suite, Redwood City, CA, 94063, USA.
George TriadafilopoulosDivision of Gastroenterology and Hepatology, Stanford University School of Medicine, 430 Broadway St, Pav C 3rd Floor, GI Suite, Redwood City, CA, 94063, USA.
Leila NeshatianDivision of Gastroenterology and Hepatology, Stanford University School of Medicine, 430 Broadway St, Pav C 3rd Floor, GI Suite, Redwood City, CA, 94063, USA. Lneshati@stanford.edu.ORCID 0000-0003-4153-5012
Stanford University · USSanta Clara Valley Medical Center · USStanford Medicine · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPostural orthostatic tachycardia syndrome (POTS) is an autonomic disorder that affects multiple organs, including the gastrointestinal system. These patients often have multiple GI complaints with a severe impact on their quality of life. GI dysmotility patterns in POTS remains poorly understood and difficult to manage.

aimsThe aim of this study was to investigate the diagnostic yield of wireless motility capsule in patients with gastrointestinal symptoms and POTS, with use of a symptomatic control group without POTS as a reference.

methodsWe retrospectively reviewed the charts of patients who had both autonomic testing and wireless motility capsule between 2016 and 2020. The two groups were divided into those with POTS and those without POTS (controls) as diagnosed through autonomic testing. We compared the regional transit times and motility patterns between the two groups using the data collected from wireless motility capsule.

resultsA total of 25% of POTS patients had delayed small bowel transit compared to 0% of non-POTS patients (p = 0.047). POTS patients exhibited hypo-contractility patterns within the small bowel, including decreased contractions/min (2.95 vs. 4.22, p = 0.011) and decreased motility index (101.36 vs. 182.11, p = 0.021). In multivariable linear regression analysis, migraine predicted faster small bowel transit (p = 0.007) and presence of POTS predicted slower small bowel transit (p = 0.044).

conclusionsMotility abnormalities among POTS patients seem to affect mostly the small bowel and exhibit a general hypo-contractility pattern. Wireless motility capsule can be a helpful tool in patients with POTS and GI symptoms as it can potentially help guide treatment.

Indexed as

Gastrointestinal TransitAdultCapsule EndoscopyFemaleHumansIntestine, SmallMalePostural Orthostatic Tachycardia SyndromeRetrospective StudiesGastrointestinal transitGastroparesisPostural orthostatic tachycardia syndrome (POTS)Slow transit constipationSmall bowel dysmotilityWireless motility capsule

Identifiers

PMID33428036
OpenAlexW3118405617

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.