Evidence map›Paper›PMID 33427950›Full record

ReviewCurrent genetics2021

Checkpoint functions of RecQ helicases at perturbed DNA replication fork.

Nafees Ahamad, Saman Khan, Alaa Taha A Mahdi, Yong-Jie Xu

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Smc5/6 Complex Promotes Rad3Molecular and cellular biology · 2022
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Nafees AhamadDepartment of Pharmacology and Toxicology, Boonshoft School of Medicine, Wright State University, Dayton, OH, USA.
Saman KhanDepartment of Pharmacology and Toxicology, Boonshoft School of Medicine, Wright State University, Dayton, OH, USA.
Alaa Taha A MahdiDepartment of Pharmacology and Toxicology, Boonshoft School of Medicine, Wright State University, Dayton, OH, USA.
Yong-Jie XuDepartment of Pharmacology and Toxicology, Boonshoft School of Medicine, Wright State University, Dayton, OH, USA. yong-jie.xu@wright.edu.ORCID http://orcid.org/0000-0002-5091-5247
Wright State University · US

Funding

Signaling Mechanism of the DNA Replication CheckpointR01GM110132 · NIGMS · WRIGHT STATE UNIVERSITY · PI XU, YONGJIE · 2015 to 2020
$1.3M
NIGMS NIH HHS GM110132NIGMS NIH HHS R01 GM110132
6 · The paper itself

Abstract

DNA replication checkpoint is a cell signaling pathway that is activated in response to perturbed replication. Although it is crucial for maintaining genomic integrity and cell survival, the exact mechanism of the checkpoint signaling remains to be understood. Emerging evidence has shown that RecQ helicases, a large family of helicases that are conserved from bacteria to yeasts and humans, contribute to the replication checkpoint as sensors, adaptors, or regulation targets. Here, we highlight the multiple functions of RecQ helicases in the replication checkpoint in four model organisms and present additional evidence that fission yeast RecQ helicase Rqh1 may participate in the replication checkpoint as a sensor.

Indexed as

Cell Cycle CheckpointsDNA HelicasesDNA ReplicationHumansRecQ HelicasesSchizosaccharomycesSchizosaccharomyces pombe ProteinsSignal TransductionDNA HelicasesRecQ HelicasesRqh1 protein, S pombeSchizosaccharomyces pombe ProteinsATRBLMBudding yeastCds1CHK1DNA replication checkpointFission yeastGenomic instabilityHelicaseMec1Rad3RecQRECQ1RECQ4RECQ5Replication stressRqh1Sgs1SOS responseWRN

Identifiers

PMID33427950
OpenAlexW3119362581

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.