SynthesisMovement disorders : official journal of the Movement Disorder Society2021
Brain Motor Network Changes in Parkinson's Disease: Evidence from Meta-Analytic Modeling.
Synthesis in Movement disorders : official journal of the Movement Disorder Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05169827 (How Cerebral Plasticity Shapes Symptom Progression in Parkinson's Disease), which is not on this map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
How Cerebral Plasticity Shapes Symptom Progression in Parkinson's Disease: a Longitudinal Neuroimaging Study
Who cites it
26 citing papers in PubMed, 46 citations in OpenAlex.
- Functional segregation in Parkinson's disease.Science advances · 2026Article
- Auditory cueing modulates motor performance and brain activity in early Parkinson's disease-a kinematic and fMRI study.NPJ Parkinson's disease · 2026Article
- Plasticity-Induced Motor Recovery of Bilateral Intermittent Theta Burst Stimulation in Parkinson's Disease: A Randomized, Double-Blind, Sham-Controlled, Crossover Trial.Neurology and therapy · 2026Article
- Parkinson's disease progression is shaped by longitudinal changes in cerebral compensation.Brain : a journal of neurology · 2026Article
- Basal ganglia as an fMRI motor neurofeedback target in Parkinson's disease.Applied psychophysiology and biofeedback · 2025Article
- Ikelos-Rating Scale: Validation of a Behavioural Severity Marker in REM Sleep Behaviour Disorder.Journal of sleep research · 2025Article
- Micrographia in Parkinson's Disease: Automatic Recognition through Artificial Intelligence.Movement disorders clinical practice · 2025Article
- Understanding individual neurodegenerative progression in Parkinson's disease through normative modelling.Scientific reports · 2025Article
- Self-Perception of Drooling Impact in People with Parkinson's Disease: A Case-Control and Cross-Sectional Study.Movement disorders clinical practice · 2025Article
- Non-invasive brain stimulation to modulate neural activity in Parkinson's disease.NPJ Parkinson's disease · 2025Review
- Attention-based Transformer-LSTM architecture for early diagnosis and staging of early-stage Parkinson's disease using fNIRS data.Frontiers in aging neuroscience · 2025Article
- Assessing age-related changes in brain activity during isometric upper and lower limb force control tasks.Brain structure & function · 2024Article
- Neural correlates of bradykinesia in Parkinson's disease: a kinematic and functional MRI study.NPJ Parkinson's disease · 2024Article
- Neuroimaging and fluid biomarkers in Parkinson's disease in an era of targeted interventions.Nature communications · 2024Review
- Presynaptic Dopaminergic Imaging Characterizes Patients with REM Sleep Behavior Disorder Due to Synucleinopathy.Annals of neurology · 2024Article
- Oscillatory and non-oscillatory features of the magnetoencephalic sensorimotor rhythm in Parkinson's disease.NPJ Parkinson's disease · 2024Article
- Clinical severity in Parkinson's disease is determined by decline in cortical compensation.Brain : a journal of neurology · 2024Article
- Neurocognitive correlates of semantic memory navigation in Parkinson's disease.NPJ Parkinson's disease · 2024Article
- Functional brain controllability in Parkinson's disease and its association with motor outcomes after deep brain stimulation.Frontiers in neuroscience · 2024Article
- Improving efficacy of repetitive transcranial magnetic stimulation for treatment of Parkinson disease gait disorders.Frontiers in human neuroscience · 2024Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundMotor-related brain activity in Parkinson's disease has been investigated in a multitude of functional neuroimaging studies, which often yielded apparently conflicting results. Our previous meta-analysis did not resolve inconsistencies regarding cortical activation differences in Parkinson's disease, which might be related to the limited number of studies that could be included. Therefore, we conducted a revised meta-analysis including a larger number of studies. The objectives of this study were to elucidate brain areas that consistently show abnormal motor-related activation in Parkinson's disease and to reveal their functional connectivity profiles using meta-analytic approaches.
methodsWe applied a quantitative meta-analysis of functional neuroimaging studies testing limb movements in Parkinson's disease comprising data from 39 studies, of which 15 studies (285 of 571 individual patients) were published after the previous meta-analysis. We also conducted meta-analytic connectivity modeling to elucidate the connectivity profiles of areas showing abnormal activation.
resultsWe found consistent motor-related underactivation of bilateral posterior putamen and cerebellum in Parkinson's disease. Primary motor cortex and the supplementary motor area also showed deficient activation, whereas cortical regions localized directly anterior to these areas expressed overactivation. Connectivity modeling revealed that areas showing decreased activation shared a common pathway through the posterior putamen, whereas areas showing increased activation were connected to the anterior putamen.
conclusionsDespite conflicting results in individual neuroimaging studies, this revised meta-analytic approach identified consistent patterns of abnormal motor-related activation in Parkinson's disease. The distinct patterns of decreased and increased activity might be determined by their connectivity with different subregions of the putamen. © 2021 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.