Evidence map›Paper›PMID 33427061›Full record

ArticleAmerican journal of physiology. Renal physiology2021

Proximal tubule LPA1 and LPA2 receptors use divergent signaling pathways to additively increase profibrotic cytokine secretion.

Hui Geng, Rongpei Lan, Yaguang Liu, Wei Chen, Meng Wu, Pothana Saikumar, Joel M Weinberg, Manjeri A Venkatachalam

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Renal physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Review
  3. Role of G protein coupled receptors in acute kidney injury.Cell communication and signaling : CCS · 2024
    Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Hui GengDepartment of Pathology, University of Texas Health Science Center, San Antonio, Texas.ORCID 0000-0001-7787-9664
Rongpei LanDepartment of Pathology, University of Texas Health Science Center, San Antonio, Texas.
Yaguang LiuDepartment of Pathology, University of Texas Health Science Center, San Antonio, Texas.
Wei ChenDepartment of Pathology, University of Texas Health Science Center, San Antonio, Texas.
Meng WuDepartment of Pathology, University of Texas Health Science Center, San Antonio, Texas.
Pothana SaikumarDepartment of Pathology, University of Texas Health Science Center, San Antonio, Texas.
Joel M WeinbergDepartment of Medicine, University of Michigan Medical Center, Ann Arbor, Michigan.
Manjeri A VenkatachalamDepartment of Pathology, University of Texas Health Science Center, San Antonio, Texas.
The University of Texas Health Science Center at San Antonio · USUniversity of Michigan · US

Funding

Pathogenesis of tubule atrophy and failed recovery after acute kidney injuryR01DK104128 · NIDDK · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI VENKATACHALAM, MANJERI A · 2016 to 2019
$1.4M
Mitochondrial Recovery after Acute Kidney Injury Needs Ribonucleotide ReductaseR01DK119693 · NIDDK · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI VENKATACHALAM, MANJERI A · 2020 to 2022
$696k
NIDDK NIH HHS R01 DK104128NIDDK NIH HHS R01 DK119693
6 · The paper itself

Abstract

Lysophosphatidic acid (LPA) increases platelet-derived growth factor-B (PDGFB) and connective tissue growth factor (CTGF) production and secretion by proximal tubule (PT) cells through LPA2 receptor-G

Indexed as

Acute Kidney InjuryAnimalsCell LineConnective Tissue Growth FactorCytokinesDisease Models, AnimalErbB ReceptorsExtracellular Signal-Regulated MAP KinasesFibrosisHumansJNK Mitogen-Activated Protein KinasesKidney Tubules, ProximalLymphokinesMaleMicePhosphorylationCCN2 protein, mouseConnective Tissue Growth FactorCytokinesEGFR protein, mouseErbB ReceptorsExtracellular Signal-Regulated MAP KinasesJNK Mitogen-Activated Protein KinasesLPAR1 protein, mouseLymphokinesPdgfd protein, mousePlatelet-Derived Growth FactorReceptors, Lysophosphatidic AcidTgfb1 protein, mouseTranscription Factor AP-1Transforming Growth Factor beta1acute kidney injuryfibrosiskidneylysophosphatidic acid receptors

Identifiers

PMID33427061
PMCPMC7988817
OpenAlexW3118251246

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.