Evidence map›Paper›PMID 33427053›Full record

ArticleAmerican journal of physiology. Endocrinology and metabolism2021

Prematurity blunts the insulin- and amino acid-induced stimulation of translation initiation and protein synthesis in skeletal muscle of neonatal pigs.

Marko Rudar, Jane K Naberhuis, Agus Suryawan, Hanh V Nguyen, Barbara Stoll, Candace C Style, Mariatu A Verla, Oluyinka O Olutoye, Douglas G Burrin, Marta L Fiorotto and 1 more

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Endocrinology and metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Amino acids and lean mass accretion in preterm neonates.Current opinion in clinical nutrition and metabolic care · 2026
    Review
  5. Review
  6. Article
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  13. Review: Nutritional regulation of muscle growth in neonatal swine.Animal : an international journal of animal bioscience · 2023
    Review
  14. Article
  15. Fibroblast growth factor 19 secretion and function in perinatal development.American journal of physiology. Gastrointestinal and liver physiology · 2023
    Review
  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Marko RudarUnited States Department of Agriculture/Agricultural Research Service Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas.
Jane K NaberhuisUnited States Department of Agriculture/Agricultural Research Service Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas.
Agus SuryawanUnited States Department of Agriculture/Agricultural Research Service Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas.
Hanh V NguyenUnited States Department of Agriculture/Agricultural Research Service Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas.
Barbara StollUnited States Department of Agriculture/Agricultural Research Service Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas.
Candace C StyleDivision of Pediatric Surgery, Michael E. DeBakey Department of Surgery, Texas Children's Hospital, Baylor College of Medicine, Houston, Texas.
Mariatu A VerlaDivision of Pediatric Surgery, Michael E. DeBakey Department of Surgery, Texas Children's Hospital, Baylor College of Medicine, Houston, Texas.
Oluyinka O OlutoyeDivision of Pediatric Surgery, Michael E. DeBakey Department of Surgery, Texas Children's Hospital, Baylor College of Medicine, Houston, Texas.
Douglas G BurrinUnited States Department of Agriculture/Agricultural Research Service Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas.
Marta L FiorottoUnited States Department of Agriculture/Agricultural Research Service Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas.ORCID 0000-0001-8475-4704
Teresa A DavisUnited States Department of Agriculture/Agricultural Research Service Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas.ORCID 0000-0002-4610-9795
Agricultural Research Service · USBaylor College of Medicine · US

Funding

REGULATION OF NEONATAL MUSCLE PROTEIN SYNTHESISR01HD085573 · NICHD · TEXAS A&M AGRILIFE RESEARCH · PI TERESA A DAVIS · 2016 to 2026
$4.7M
Regulation of Neonatal Muscle Protein SynthesisR01AR044474 · NIAMS · BAYLOR COLLEGE OF MEDICINE · PI DAVIS, TERESA A · 1996 to 2012
$4.2M
Leucine Supplementation to Promote Lean Growth in Early LifeR01HD072891 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI DAVIS, TERESA A · 2012 to 2015
$1.4M
Leucine and HMB Supplementation in Early Life to Promote Muscle Growth at the Expense of Adipose DepositionR01HD099080 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI DAVIS, TERESA A, FIOROTTO, MARTA L · 2019 to 2021
$1.2M
HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) HD-072891HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) HD-085573HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) HD-099080NIAMS NIH HHS R01 AR044474NICHD NIH HHS R01 HD072891NICHD NIH HHS R01 HD085573NICHD NIH HHS R01 HD099080USDA | National Institute of Food and Agriculture (NIFA) 2013-67015-20438U.S. Department of Agriculture CRIS 3092-51000-060
6 · The paper itself

Abstract

Extrauterine growth restriction in premature infants is largely attributed to reduced lean mass accretion and is associated with long-term morbidities. Previously, we demonstrated that prematurity blunts the feeding-induced stimulation of translation initiation signaling and protein synthesis in skeletal muscle of neonatal pigs. The objective of the current study was to determine whether the blunted feeding response is mediated by reduced responsiveness to insulin, amino acids, or both. Pigs delivered by cesarean section preterm (PT; 103 days,

Indexed as

Amino AcidsAnimalsAnimals, NewbornFemaleInsulinMechanistic Target of Rapamycin Complex 1Muscle, SkeletalPeptide Chain Initiation, TranslationalPregnancyPremature BirthProtein BiosynthesisSignal TransductionSwineAmino AcidsInsulinMechanistic Target of Rapamycin Complex 1amino acidinsulinmTORprematurityprotein synthesis

Identifiers

PMID33427053
PMCPMC7988778
OpenAlexW3120190322

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.