ArticleAmerican journal of physiology. Endocrinology and metabolism2021
IGF-1 infusion to fetal sheep increases organ growth but not by stimulating nutrient transfer to the fetus.
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Article in American journal of physiology. Endocrinology and metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
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Who cites it
20 citing papers in PubMed, 25 citations in OpenAlex.
- Integrated Assessment of Metabolic, Oxidative, and Molecular Adaptations from Pregnancy to Early Lactation in Shami Goats (Veterinary sciences · 2026Article
- Oxygen and glucose supplementation increases rates of linear growth and cell proliferation in growth-restricted fetal sheep.The Journal of physiology · 2026Article
- Placenta hIGF1 nanoparticle treatment in guinea pigs mitigates fetal sex dependent FGR-associated effects on kidney structure and blood pressure-related signaling pathways.Life sciences · 2025Article
- Genome-wide identification of selection signatures across altitudinal gradients in dairy sheep breeds.Scientific reports · 2025Article
- Fetal programming under maternal heat stress: a focus on skeletal muscle growth and nutrition in livestock.Journal of developmental origins of health and disease · 2025Review
- Placental nanoparticle-mediated IGF1 gene therapy corrects fetal growth restriction in a guinea pig model.Gene therapy · 2025Article
- PlacentaAmerican journal of physiology. Endocrinology and metabolism · 2025Article
- IGF-1 LR3 does not promote growth in late-gestation growth-restricted fetal sheep.American journal of physiology. Endocrinology and metabolism · 2025Article
- IGF-1 infusion increases growth in fetal sheep when euinsulinemia is maintained.The Journal of endocrinology · 2024Article
- Serum insulin-like growth factor-1 and leptin concentrations in Black Bengal goats at different ages and gestation periods and their relationship to kid growth performance.Veterinary world · 2024Article
- Metabolic profile and gene expression pattern of cytokines and antioxidants markers during different physiological stages in Barki ewes.BMC veterinary research · 2024Article
- Attenuated glucose-stimulated insulin secretion during an acute IGF-1 LR3 infusion into fetal sheep does not persist in isolated islets.Journal of developmental origins of health and disease · 2023Article
- Chronic Fetal Leucine Infusion Increases Rate of Leucine Oxidation but Not of Protein Synthesis in Late Gestation Fetal Sheep.The Journal of nutrition · 2023Article
- Artificial placenta support of extremely preterm ovine fetuses at the border of viability for up to 336 hours with maintenance of systemic circulation but reduced somatic and organ growth.Frontiers in physiology · 2023Article
- Dousing the flame: reviewing the mechanisms of inflammatory programming during stress-induced intrauterine growth restriction and the potential for ω-3 polyunsaturated fatty acid intervention.Frontiers in physiology · 2023Review
- In vivo investigation of ruminant placenta function and physiology-a review.Journal of animal science · 2022Review
- Fetal Sex Does Not Impact Placental Blood Flow or Placental Amino Acid Transfer in Late Gestation Pregnant Sheep With or Without Placental Insufficiency.Reproductive sciences (Thousand Oaks, Calif.) · 2022Article
- Sheep recombinant IGF-1 promotes organ-specific growth in fetal sheep.Frontiers in physiology · 2022Article
- Reduced glucose-stimulated insulin secretion following a 1-wk IGF-1 infusion in late gestation fetal sheep is due to an intrinsic islet defect.American journal of physiology. Endocrinology and metabolism · 2021Article
- A Two-Week Insulin Infusion in Intrauterine Growth Restricted Fetal Sheep at 75% Gestation Increases Skeletal Myoblast Replication but Did Not Restore Muscle Mass or Increase Fiber Number.Frontiers in endocrinology · 2021Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Jane StremmingDepartment of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, Colorado.ORCID 0000-0002-8517-2463
Sara HeardDepartment of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, Colorado.
Alicia WhiteDepartment of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, Colorado.ORCID 0000-0003-1829-8346
Eileen I ChangDepartment of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, Colorado.ORCID 0000-0002-3444-7260
Steven C ShawDepartment of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, Colorado.
Stephanie R WesolowskiDepartment of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, Colorado.
Sonnet S JonkerKnight Cardiovascular Institute, Center for Developmental Health, Oregon Health & Science University, Portland, Oregon.ORCID 0000-0002-1097-2562
Paul J RozanceDepartment of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, Colorado.
Laura D BrownDepartment of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, Colorado.ORCID 0000-0002-0292-5029
University of Colorado Anschutz Medical Campus · USOregon Health & Science University · US
Funding
PILOT STUDY--SUBSTRATE METABOLISM IN EXTREMELY LOW BIRTH WEIGHT INFANTSP30DK048520 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI Wendy M Kohrt · 1995 to 2026
$32.6MTraining Program in Perinatal Biology and MedicineT32HD007186 · NICHD · UNIVERSITY OF COLORADO DENVER · PI Paul Joseph Rozance · 1985 to 2026
$6.5MNutrient Coordination of Pancreatic Vasculature and Beta-CellsR01DK088139 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI ROZANCE, PAUL JOSEPH · 2011 to 2020
$5.1MRegulation of Fetal Skeletal Muscle Growth in IUGRR01HD079404 · NICHD · UNIVERSITY OF COLORADO DENVER · PI Laura Davidson Brown · 2015 to 2026
$4.7MNutrient and Insulin Metabolic Actions in IUGR Fetal LiverR01DK108910 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI Stephanie R Wesolowski · 2017 to 2026
$4.3MPhysiological Ramifications of Chorionic Somatomammotropin DeficiencyR01HD093701 · NICHD · UNIVERSITY OF COLORADO DENVER · PI ANTHONY, RUSSELL V, ROZANCE, PAUL JOSEPH · 2018 to 2022
$2.9MPerinatal cardiomyocyte pruning driven by metabolic maturation: Opportunity for interventionR01HL142483 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI JONKER, SONNET SKY · 2019 to 2022
$2.7MMechanisms of Fetal Myocardial and Coronary Growth SynchronyR01HD071068 · NICHD · OREGON HEALTH & SCIENCE UNIVERSITY · PI JONKER, SONNET SKY · 2012 to 2016
$1.6MUV-visible HPLC with PCX Pinnacle post column reaction moduleS10OD023553 · OD · UNIVERSITY OF COLORADO DENVER · PI BROWN, LAURA DAVIDSON · 2017 to 2017
$98kHHS | National Institutes of Health (NIH) R01DK088139HHS | National Institutes of Health (NIH) R01DK108910HHS | National Institutes of Health (NIH) R01HD071068HHS | National Institutes of Health (NIH) R01HD079404HHS | National Institutes of Health (NIH) R01HD093701HHS | National Institutes of Health (NIH) R01HL142483HHS | National Institutes of Health (NIH) S10OD023553HHS | National Institutes of Health (NIH) T32HD007186NHLBI NIH HHS R01 HL142483NICHD NIH HHS R01 HD071068NICHD NIH HHS R01 HD079404NICHD NIH HHS R01 HD093701NICHD NIH HHS T32 HD007186NIDDK NIH HHS P30 DK048520NIDDK NIH HHS R01 DK088139NIDDK NIH HHS R01 DK108910NIH HHS S10 OD023553
Abstract
Insulin-like growth factor-1 (IGF-1) is an important fetal growth factor. However, the role of fetal IGF-1 in increasing placental blood flow, nutrient transfer, and nutrient availability to support fetal growth and protein accretion is not well understood. Catheterized fetuses from late gestation pregnant sheep received an intravenous infusion of LR3 IGF-1 (LR3 IGF-1;
Indexed as
AnimalsEnergy MetabolismFemaleFetal BloodFetal DevelopmentFetal WeightFetusInsulin-Like Growth Factor IMaleMuscle, SkeletalNutrientsOrgan SizePlacentaPlacentationPregnancySheepInsulin-Like Growth Factor INutrientsamino acidsfetal growthumbilical substrate uptakeuterine substrate uptake
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.