Evidence map›Paper›PMID 33427027›Full record

ArticleCell cycle (Georgetown, Tex.)2021

Expression of miRNA-203 and its target gene in hair follicle cycle development of Cashmere goat.

Tao Ma, Jianyu Li, Jianping Li, Sufang Wu, Xiangba, Huaizhi Jiang, Qialling Zhang

Open access · bronzeAbstract read
In one paragraph

Article in Cell cycle (Georgetown, Tex.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Tao MaCollege of Veterinary Medicine, Jilin University , Changchun, China.
Jianyu LiCollege of Veterinary Medicine, Jilin University , Changchun, China.
Jianping LiCollege of Animal Science and Technology, Jilin Agricultural Science and Technology University , Jilin, China.
Sufang WuCollege of Veterinary Medicine, Jilin University , Changchun, China.
XiangbaCollege of Veterinary Medicine, Jilin University , Changchun, China.
Huaizhi JiangCollege of Animal Science and Technology, Jilin Agricultural University , Changchun, China.
Qialling ZhangCollege of Veterinary Medicine, Jilin University , Changchun, China.ORCID 0000-0002-0856-1334
Jilin University · CNJilin Agricultural University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

MicroRNA plays an important regulatory role in the development of all organisms, including hair follicle development. In order to improve domestic cashmere yield, the role of miRNA in hair follicle cycle has become a research hotspot. However, the molecular and cellular mechanisms by which miRNA-203 regulates hair follicle development are not completely understood. In this study, we found that the relevant target genes of miRNA-203 (DDOST and NAE1) were less expressed in telogen by qPCR and Immunoblotting analysis, contrary to the expression mode of miRNA-203. The Dual-Luciferase reporter assay was used to verify the correlation between miRNA-203 and its target gene expression. The results showed that miRNA-203 specifically binds to the 3 'UTR of DDOST and NAE1, and the expression of miRNA-203 significantly down-regulates the expression of DDOST and NAE1 mRNA and protein. Therefore, this study demonstrates that miRNA-203 may regulate hair follicle development in Cashmere goats by targeting DDOST and NAE1.

Indexed as

AnimalsGene Expression ProfilingGoatsHair FollicleMicroRNAsOrganogenesisReal-Time Polymerase Chain ReactionRNA, Long NoncodingRNA, MessengerMicroRNAsRNA, Long NoncodingRNA, MessengerCashmere goatDDOSTHair follicle cycleNAE1

Identifiers

PMID33427027
PMCPMC7889112
OpenAlexW3120166369

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.