ArticleJournal of veterinary internal medicine2021
Serum spexin concentration, body condition score and markers of obesity in dogs.
Article in Journal of veterinary internal medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 9 citations in OpenAlex.
- Nephroprotective effect of spexin in dogs and cats.BMC veterinary research · 2026Article
- Immunoexpression of Spexin in Selected Segments of the Bovine (Animals : an open access journal from MDPI · 2023Article
- Recommendations for Designing, Conducting and Reporting Clinical Observational Studies in Homeopathic Veterinary Medicine.Homeopathy : the journal of the Faculty of Homeopathy · 2023Review
- Serum spexin concentration, body condition score and markers of obesity in dogs.Journal of veterinary internal medicine · 2021Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
backgroundSpexin (SPX) is a peptide hormone that regulates body weight, adipose tissue metabolism, and food intake. HYPOTHESIS: Serum SPX concentration correlates with body condition score (BCS) and markers of obesity in dogs. ANIMALS: Fifty-seven dogs of varying body condition assessed using a 5-point BCS.
methodsProspective, nonblinded, observational cohort study. Serum SPX concentration was measured using commercially available radioimmunoassay (RIA) in dogs with varying BCS. Spexin mRNA and protein expression were detected using real-time quantitative polymerase chain reaction and immunofluorescence staining.
resultsSerum SPX concentration was lower in dogs with BCS4 (8.56 +/- 2.86) and BCS5 (6.7 +/- 2.12) compared to BCS2 (11.96 +/- 2.23) and BCS3 (10.51 +/- 2.19; BCS2 vs BCS5, P < .001 and BCS2 vs BCS4, P = .005; BCS3 vs BCS5, P = .002). Spexin mRNA was detected in adipose tissue, liver and pancreas. Spexin protein was expressed in adipose tissue and liver but not in pancreas. There were negative correlations between SPX and serum concentration of insulin (P < .05); leptin (P < .01), triglycerides (P < .01), total cholesterol (P < .01), nonesterified fatty acids (P < .01), and fructosamine (P < .01). There was a positive correlation between SPX and serum concentration of adiponectin (P < .01). CONCLUSIONS AND CLINICAL IMPORTANCE: Spexin could be involved in pathogenesis of obesity in dogs, and might be considered as a potential marker for obesity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.