Evidence map›Paper›PMID 33426669›Full record

ReviewAnaesthesia2021

The role of regional anaesthesia and multimodal analgesia in the prevention of chronic postoperative pain: a narrative review.

Y-Y K Chen, K A Boden, K L Schreiber

3 registry-linked trialsOpen access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Anaesthesia, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 106 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
106citing papers in PubMed, 2 pooled it
26.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05981105 narecruitingnot on this mapstarted 2023, after this paper: background citation

Expanding the Peri-operative Surgical Home Model: ERAS TKR With a Transitional Pain Service (TeleTPS) - Continuous Adductor Canal Catheter Versus Adductor Canal Block for Total Knee Arthroplasty, a Randomized Double-blinded Controlled Trial.

TypeinterventionalSponsorHospital for Special Surgery, New YorkRan2023 to 2027Enrolled64ConditionsChronic Pain, Opioid Use, Adductor Canal Block, Total Knee ArthroplastyArmsambIT pump with catheter, ambIT pump with sham catheter
NCT06187922 phase4unknown statusnot on this mapstarted 2023, after this paper: background citation

Effect of Perioperative Oral Pregabalin in Total Knee Replacement for Postoperative Pain

TypeinterventionalSponsorBahrain Defence Force HospitalRan2023 to 2025Enrolled120ConditionsPostoperative PainArmsPregabalin 75mg, adductor canal block
NCT06466941 recruitingnot on this mapstarted 2024, after this paper: background citation

Impact of Patient Phenotypic Features on the Experience and Effectiveness of Regional Anesthesia and Postoperative Pain

TypeobservationalSponsorBrigham and Women's HospitalRan2024 to 2028Enrolled1,000ConditionsAcute Pain, Chronic Post Operative Pain, Opioid UseArmsregional anesthesia, no regional anesthesia, acute pain consultation, no acute pain consultation
3 · Its place in the literature

Who cites it

106 citing papers in PubMed, 2 syntheses or guidelines pooled it, 205 citations in OpenAlex.

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  18. Preoperative Quadratus Lumborum Block Reduces Opioid Requirements in the Immediate Postoperative Period Following Hip Arthroscopy: A Randomized, Blinded Clinical Trial.Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association · 2022
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46 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Y-Y K ChenDepartment of Anesthesiology, Peri-operative and Pain Medicine, Brigham and Women's Hospital, Boston, MA, USA.ORCID 0000-0002-3770-2749
K A BodenDepartment of Anesthesiology, Peri-operative and Pain Medicine, Brigham and Women's Hospital, Boston, MA, USA.
K L SchreiberDepartment of Anesthesiology, Peri-operative and Pain Medicine, Brigham and Women's Hospital, Boston, MA, USA.ORCID 0000-0002-7361-2214
Brigham and Women's Hospital · US

Funding

Personalizing Perioperative Preventive Analgesia: Translational Studies Investigating the Biopsychosocial Underpinnings of Enhanced Pain PropensityR35GM128691 · NIGMS · STANFORD UNIVERSITY · PI KRISTIN SCHREIBER · 2018 to 2026
$4.3M
NIGMS NIH HHS R35 GM128691
6 · The paper itself

Abstract

Effective prevention of chronic postoperative pain is an important clinical goal, informed by a growing body of studies. Peri-operative regional anaesthesia remains one of the most important tools in the multimodal analgesic toolbox, blocking injury-induced activation and sensitisation of both the peripheral and central nervous system. We review the definition and taxonomy of chronic postoperative pain, its mechanistic basis and the most recent evidence for the preventative potential of multimodal analgesia, with a special focus on regional anaesthesia. While regional anaesthesia targets several important aspects of the mechanistic pathway leading to chronic postoperative pain, evidence for its efficacy is still mixed, possibly owing to the heterogeneity of risk profiles within the surgical patient, but also to variation in techniques and medications reported in the literature.

Indexed as

AnalgesiaAnesthesia, ConductionChronic PainHumansPain ManagementPostoperative PainRisk Factorschronic postoperative painmultimodal analgesiaregional anaesthesia

Identifiers

PMID33426669
PMCPMC8369227
OpenAlexW3119249525

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.