ArticleArchives of toxicology2021
Transcriptomics analysis of hepatotoxicity induced by the pesticides imazalil, thiacloprid and clothianidin alone or in binary mixtures in a 28-day study in female Wistar rats.
Article in Archives of toxicology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 16 citations in OpenAlex.
- Biomonitoring-informed neonicotinoid mixture exposure reveals modest cytotoxicity and cell-type-specific molecular responses in human cell lines.BMC pharmacology & toxicology · 2026Article
- Shared Mechanism, Distinct Outcomes: Transcriptomic Analysis Reveals Differential Modulation of Metabolic and Detoxification Pathways by Neonicotinoid Insecticides.International journal of molecular sciences · 2026Article
- Comparative habitat-associated patterns of pathomorphological changes in the internal organs of the European brown hare (Veterinary world · 2026Article
- Comparative transcriptomic points of departure analysis of pesticides in human Caco-2 and Hep G2 cells.NAM journal · 2026Article
- From toxicogenomics data to cumulative assessment groups: a framework for chemical grouping.Archives of toxicology · 2026Article
- A benchmark concentration-based strategy for evaluating the combined effects of genotoxic compounds in TK6 cells.Archives of toxicology · 2025Article
- Deletion of Constitutive Androstane Receptor Led to Intestinal Alterations and Increased Imidacloprid in Murine Liver.Journal of the Endocrine Society · 2022Article
- Mixture Math: Deciding What to Add in a Cumulative Risk Assessment.Current opinion in toxicology · 2022Article
- Use of transcriptomics in hazard identification and next generation risk assessment: A case study with clothianidin.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2022Article
- Mixture prioritization and testing: the importance of toxicokinetics.Archives of toxicology · 2021Article
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8 authors at 1 institution in 1 country.
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Abstract
Co-occurrence of pesticide residues in food commodities raises a potential safety issue as their mixture effects on human health are largely unknown. In a previous study, we reported the toxicological effects (pathology and histopathology) of imazalil (IMZ), thiacloprid (THI), and clothianidin (CTD) alone and in binary mixtures in a 28-day oral gavage study in female Wistar rats. Five dose levels (up to 350 mg/kg body weight/day) ranging from a typical toxicological reference value to a clear effect dose were applied. In the present study, we undertook a transcriptomics analysis of rat livers by means of total RNA sequencing (RNA-Seq). Bioinformatic data analysis involving Ingenuity Pathway Analysis (IPA) was used to gain mechanistic information on hepatotoxicity-related pathways affected after treatment with the pesticides, alone and in mixtures. Our data show that 2986 genes were differentially regulated by CTD while IMZ and THI had effects on 194 and 225 genes, respectively. All three individual compounds shared a common subset of genes whose network is associated with xenobiotic metabolism and nuclear receptor activation. Similar networks were retrieved for the mixtures. Alterations in the expression of individual genes were in line with the assumption of dose addition. Our results bring new insight into the hepatotoxicity mechanisms of IMZ, THI, and CTD and their mixtures.
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