Evidence map›Paper›PMID 33426512›Full record

ArticleiScience2021

Impaired host response and the presence of

Dasith Perera, Sarah E Kleinstein, Benjamin Hanson, Hatice Hasturk, Ryan Eveloff, Marcelo Freire, Matthew Ramsey

Open access · goldAbstract read
In one paragraph

Article in iScience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Hypoglycemic Effects ofMolecules (Basel, Switzerland) · 2026
    Article
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  7. Article
  8. Review
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  10. Review
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  13. Article
  14. Acinetobacter baumannii as an oro-dental pathogen: a red alert!!Journal of applied oral science : revista FOB · 2024
    Review
  15. Short-chain fatty acids in diseases.Cell communication and signaling : CCS · 2023
    Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Dasith PereraThe University of Rhode Island, Department of Cell and Molecular Biology, Kingston, RI 02881, USA.
Sarah E KleinsteinJ. Craig Venter Institute, La Jolla, CA 92037, USA.
Benjamin HansonThe University of Rhode Island, Department of Cell and Molecular Biology, Kingston, RI 02881, USA.
Hatice HasturkThe Forsyth Institute, Cambridge, MA 02142, USA.
Ryan EveloffJ. Craig Venter Institute, La Jolla, CA 92037, USA.
Marcelo FreireJ. Craig Venter Institute, La Jolla, CA 92037, USA.
Matthew RamseyThe University of Rhode Island, Department of Cell and Molecular Biology, Kingston, RI 02881, USA.
J. Craig Venter Institute · USUniversity of Rhode Island · US

Funding

Training CoreP20GM103430 · NIGMS · UNIVERSITY OF RHODE ISLAND · PI Christopher Lee Hemme · 2012 to 2026
$63.6M
Mechanisms underlying spatial interaction in the oral microbiotaR01DE027958 · NIDCR · UNIVERSITY OF RHODE ISLAND · PI RAMSEY, MATTHEW · 2019 to 2023
$1.9M
Regulation of ChemR23 in Resolution of InflammationR00DE023584 · NIDCR · J. CRAIG VENTER INSTITUTE, INC. · PI FREIRE, MARCELO · 2015 to 2019
$1.2M
Treatment of Periodontitis and Inflammatory Changes in DiabetesK23DE018917 · NIDCR · BOSTON UNIVERSITY MEDICAL CAMPUS · PI HASTURK, HATICE · 2008 to 2012
$647k
NIDCR NIH HHS K23 DE018917NIDCR NIH HHS R00 DE023584NIDCR NIH HHS R01 DE027958NIGMS NIH HHS P20 GM103430
6 · The paper itself

Abstract

Type II diabetes (T2D) affects over 10% of the US population and is a growing disease worldwide that manifests with numerous comorbidities and defects in inflammation. This dysbiotic host response allows for infection of the host by numerous microorganisms. In the course of T2D disease, individuals can develop chronic infections including foot ulcers and periodontitis, which lead to further complications and opportunistic infections in multiple body sites. In this study, we investigated the serum of healthy subjects and patients with T2D with (T2DP) or without periodontitis for both microbiome signatures in addition to cytokine profiles. Surprisingly, we detected the presence of

Indexed as

Human MetabolismMicrobiology

Identifiers

PMID33426512
PMCPMC7779772
OpenAlexW3110836993

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.