Evidence map›Paper›PMID 33426372›Full record

ArticleBioactive materials2021

From waste of marine culture to natural patch in cardiac tissue engineering.

Yutong He, Honghao Hou, Shuqi Wang, Rurong Lin, Leyu Wang, Lei Yu, Xiaozhong Qiu

Open access · goldAbstract read
In one paragraph

Article in Bioactive materials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 52 citations in OpenAlex.

  1. Article
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  5. Materials Advances in Devices for Heart Disease Interventions.Advanced materials (Deerfield Beach, Fla.) · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Yutong HeGuangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering Department of Anatomy, School of Basic Medical Sciences, Southern Medical University, Guangdong, Guangzhou, 510515, China.
Honghao HouGuangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering Department of Anatomy, School of Basic Medical Sciences, Southern Medical University, Guangdong, Guangzhou, 510515, China.
Shuqi WangGuangdong Province Key Laboratory of Marine Biotechnology, Shantou University, Shantou, 515063, China.
Rurong LinGuangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering Department of Anatomy, School of Basic Medical Sciences, Southern Medical University, Guangdong, Guangzhou, 510515, China.
Leyu WangSchool of Biomedical Engineering, Southern Medical University, Guangzhou, 510005, China.
Lei YuGuangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering Department of Anatomy, School of Basic Medical Sciences, Southern Medical University, Guangdong, Guangzhou, 510515, China.
Xiaozhong QiuGuangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering Department of Anatomy, School of Basic Medical Sciences, Southern Medical University, Guangdong, Guangzhou, 510515, China.
Southern Medical University · CNShantou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sea squirt, as a highly invasive species and main biofouling source in marine aquaculture, has seriously threatened the biodiversity and aquaculture economy. On the other hand, a conductive biomaterial with excellent biocompatibility, and appropriate mechanical property from renewable resources is urgently required for tissue engineering patches. To meet these targets, we presented a novel and robust strategy for sustainable development aiming at the marine pollution via recycling and upgrading the waste biomass-sea squirts and serving as a renewable resource for functional bio-scaffold patch in tissue engineering. We firstly demonstrated that the tunic cellulose derived natural self-conductive scaffolds successfully served as functional cardiac patches, which significantly promote the maturation and spontaneous contraction of cardiomyocytes both in vitro and enhance cardiac function of MI rats in vivo. We believe this novel, feasible and "Trash to Treasure" strategy to gain cardiac patches via recycling the waste biomass must be promising and beneficial for marine environmental bio-pollution issue and sustainable development considering the large-scale consumption potential for tissue engineering and other applications.

Indexed as

BiofoulingCardiac tissue engineeringCelluloseMyocardial infarctionSea squirts

Identifiers

PMID33426372
PMCPMC7782558
OpenAlexW3115119884

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.