Evidence map›Paper›PMID 33426351›Full record

ArticleHeliyon2021

Safety of oral administration of high doses of ivermectin by means of biocompatible polyelectrolytes formulation.

Rafael R M Madrid, Patrick D Mathews, Ana C M F Patta, Anai P Gonzales-Flores, Carlos A B Ramirez, Vera L S Rigoni, Marcos Tavares-Dias, Omar Mertins

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
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  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Rafael R M MadridLaboratory of Nano Bio Materials (LNBM), Department of Biophysics, Paulista Medical School, Federal University of Sao Paulo (UNIFESP), 04023-062 Sao Paulo, SP, Brazil.
Patrick D MathewsLaboratory of Nano Bio Materials (LNBM), Department of Biophysics, Paulista Medical School, Federal University of Sao Paulo (UNIFESP), 04023-062 Sao Paulo, SP, Brazil.
Ana C M F PattaLaboratory of Nano Bio Materials (LNBM), Department of Biophysics, Paulista Medical School, Federal University of Sao Paulo (UNIFESP), 04023-062 Sao Paulo, SP, Brazil.
Anai P Gonzales-FloresPost-Graduate Program in Tropical Biodiversity, Federal University of Amapá, 68903-419 Macapá, AP, Brazil.
Carlos A B RamirezLaboratory of Nano Bio Materials (LNBM), Department of Biophysics, Paulista Medical School, Federal University of Sao Paulo (UNIFESP), 04023-062 Sao Paulo, SP, Brazil.
Vera L S RigoniLaboratory of Nano Bio Materials (LNBM), Department of Biophysics, Paulista Medical School, Federal University of Sao Paulo (UNIFESP), 04023-062 Sao Paulo, SP, Brazil.
Marcos Tavares-DiasEmbrapa Amapá, 68903-419 Macapá, AP, Brazil.
Omar MertinsLaboratory of Nano Bio Materials (LNBM), Department of Biophysics, Paulista Medical School, Federal University of Sao Paulo (UNIFESP), 04023-062 Sao Paulo, SP, Brazil.
Universidade Federal de São Paulo · BRInstituto de Investigaciones de la Amazonía Peruana · PE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The FDA-approved drug ivermectin is applied for treatments of onchocerciasis and lymphatic filariasis. The anti-cancer and anti-viral activities have been demonstrated stressing possibilities for the drug repurposing and therefore new information on high dosage safety is on demand. We analyzed

Indexed as

Animal modelDrug repurposingFormulationHigh dosageHistochemistryImmunofluorescence

Identifiers

PMID33426351
PMCPMC7775035
OpenAlexW3113600278

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.