ArticleHeliyon2020
Quantification of selected pharmaceutical compounds in water using liquid chromatography-electrospray ionisation mass spectrometry (LC-ESI-MS).
Article in Heliyon, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Preparation and Application of Sulfamethoxazole-Imprinted Polymer on Solid-Phase Extraction of Pharmaceuticals from Water.Polymers · 2025Article
- A Systematic Review of Estrogens as Emerging Contaminants in Water: A Global Overview Study from the One Health Perspective.Journal of xenobiotics · 2025Review
- Occurrence and temporal changes of pharmaceuticals in the Warta River in Poland during and after the COVID-19 pandemic.Scientific reports · 2025Article
- Biosorption Ability of Pharmaceutically Active Compounds byMolecules (Basel, Switzerland) · 2024Article
- Occurrence of Selected Pharmaceuticals in the East London Coastline Encompassing Major Rivers, Estuaries, and Seawater in the Eastern Cape Province of South Africa.ACS measurement science au · 2024Article
- Evaluation of the probable synergistic toxicity of selected potentiated antiretroviral and antibiotics on some aquatic biomarker organisms.Environmental monitoring and assessment · 2023Article
- Review of scientific literature on available methods of assessing organochlorine pesticides in the environment.Heliyon · 2023Review
- CaCuNanomaterials (Basel, Switzerland) · 2023Review
- Diclofenac, ibuprofen, and paracetamol biodegradation: overconsumed non-steroidal anti-inflammatories drugs at COVID-19 pandemic.Frontiers in microbiology · 2023Review
- Ecofriendly and sustainableArabian journal of chemistry · 2022Article
- Non-steroidal anti-inflammatory drugs in the era of the Covid-19 pandemic in the context of the human and the environment.The Science of the total environment · 2022Review
- Prevalence of Vancomycin-Resistant Enterococci and Antimicrobial Residues in Wastewater and Surface Water.Life (Basel, Switzerland) · 2021Article
- Application of a Low Transition Temperature Mixture for the Dispersive Liquid-Liquid Microextraction of Illicit Drugs from Urine Samples.Molecules (Basel, Switzerland) · 2021Article
- Environmental Risk Characterization of an Antiretroviral (ARV) Lamivudine in Ecosystems.International journal of environmental research and public health · 2021Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The detection and quantitation of pharmaceutical compounds (PCs) in different environmental matrices is still a challenge, due to their extremely low (ng-μg) concentrations and the lack of rapid and sensitive analytical techniques. A number of techniques, such as enzyme-linked immunosorbent assay (ELISA), chromatography, electrophoresis, and electrochemical methods have been explored. These methods are limited by their poor sensitivity. In this study, a hyphenated liquid chromatography-mass spectrometric (LC-MS) method was developed, validated, and tested for the detection and quantification of seven active pharmaceutical compounds, with solid-phase extraction for analytes recovery and separation of interference from the aqueous matrix. The sensitivity achieved for the method allowed for LODs (μg/L) of 0.0439, 0.0684, 0.1219, 0.0710, 0.1129, 0.0447, 0.0837 and LOQs (μg/L) of 0.1462, 0.2281, 0.4065, 0.2367, 0.3763, 0.1492, 0.2792, for lamivudine, acetaminophen, vancomycin, ciprofloxacin, sulfamethoxazole, diclofenac, and ivermectin, respectively, within a linear range of 0.01-0.1 μg/mL. Other ICH validation parameters are also discussed. The different PCs were positive in 61 % of the tested surface waters, with diclofenac present only in two of the sampling points. The concentrations at which they occurred were variable and ranged between ND and 398.98 μg/L.
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