ReviewBrain and neuroscience advances
Striatal and hippocampal contributions to flexible navigation in rats and humans.
Review in Brain and neuroscience advances. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Meta-analytic evidence for distinct neural correlates of conditioned versus verbally induced placebo analgesia.Nature communications · 2026Pooled it
- Experience-dependent emergence of multi-scale spatial organization during foraging in freely moving marmosets.iScience · 2026Article
- Dynamic Hippocampal-Striatal Information Flow Accompanies Behavioral Strategy Transitions During Sequential Learning in Pigeons: A Preliminary Study.Animals : an open access journal from MDPI · 2026Article
- Enhancement of response learning in male rats with intrastriatal infusions of a BDNF -TrkB agonist, 7,8-dihydroxyflavone.Behavioural brain research · 2026Article
- Environmental complexity modulates information processing and the balance between decision-making systems.Neuron · 2024Article
- Multisensory input modulates memory-guided spatial navigation in humans.Communications biology · 2023Article
- Review
- Selective neural coding of object, feature, and geometry spatial cues in humans.Human brain mapping · 2022Article
- Rapid encoding of task regularities in the human hippocampus guides sensorimotor timing.eLife · 2022Article
- Volumetric and connectivity assessment of the caudate nucleus in California sea lions and coyotes.Animal cognition · 2022Article
- Predictive maps in rats and humans for spatial navigation.Current biology : CB · 2022Article
- Sleep Leads to Brain-Wide Neural Changes Independent of Allocentric and Egocentric Spatial Training in Humans and Rats.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The hippocampus has been firmly established as playing a crucial role in flexible navigation. Recent evidence suggests that dorsal striatum may also play an important role in such goal-directed behaviour in both rodents and humans. Across recent studies, activity in the caudate nucleus has been linked to forward planning and adaptation to changes in the environment. In particular, several human neuroimaging studies have found the caudate nucleus tracks information traditionally associated with that by the hippocampus. In this brief review, we examine this evidence and argue the dorsal striatum encodes the transition structure of the environment during flexible, goal-directed behaviour. We highlight that future research should explore the following: (1) Investigate neural responses during spatial navigation via a biophysically plausible framework explained by reinforcement learning models and (2) Observe the interaction between cortical areas and both the dorsal striatum and hippocampus during flexible navigation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.