Evidence map›Paper›PMID 33426237›Full record

ArticleRegenerative therapy2021

Umbilical artery tissue contains p75 neurotrophin receptor-positive pericyte-like cells that possess neurosphere formation capacity and neurogenic differentiation potential.

Rina Fujii-Tezuka, Mika Ishige-Wada, Narihito Nagoshi, Hideyuki Okano, Hideo Mugishima, Shori Takahashi, Ichiro Morioka, Taro Matsumoto

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Regenerative therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Impaired pericyte-Müller glia interactionInternational journal of ophthalmology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Rina Fujii-TezukaDepartment of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, Japan.
Mika Ishige-WadaDepartment of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, Japan.
Narihito NagoshiDepartment of Orthopedic Surgery, Keio University School of Medicine, Tokyo, Japan.
Hideyuki OkanoDepartment of Physiology, Keio University School of Medicine, Tokyo, Japan.
Hideo MugishimaDepartment of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, Japan.
Shori TakahashiDepartment of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, Japan.
Ichiro MoriokaDepartment of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, Japan.
Taro MatsumotoDepartment of Functional Morphology, Division of Cell Regeneration and Transplantation, Nihon University School of Medicine, Tokyo, Japan.
Nihon University · JPKeio University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe p75 neurotrophin receptor (p75NTR) is known as an efficient marker for the prospective isolation of mesenchymal stem cells (MSCs) and neural crest-derived stem cells (NCSCs). To date, there is quite limited information concerning p75NTR-expressing cells in umbilical cord (UC), although UC is known as a rich source of MSCs. We show for the first time the localization, phenotype, and functional properties of p75NTR

methodsHuman UC tissue sections were subjected to immunohistochemistry for MSC markers including p75NTR. Enzymatically isolated umbilical artery (UA) cells containing p75NTR

resultsImmunohistochemical analysis revealed that p75NTR

conclusionsThese results show that UA tissue harbors p75NTR

Indexed as

ASMA, α-smooth muscle actinBDNF, bone-derived neurotrophic factorCFU-F, colony-forming unit fibroblastDAPI, 4′,6-diamino-2-phenylindoleDMEM, Dulbecco's modified Eagle mediumEdU, 5-ethynyl-2′-deoxyuridineEGF, epidermal growth factorEGFP, enhanced green fluorescent proteinFBS, fetal bovine serumFGF-2, fibroblast growth factor-2FSK, forskolinGFAP, glial fibrillary acidic proteinMAP2, microtubule-associated protein 2Mesenchymal stem cellsMSCs, mesenchymal stem cellsNCSCs, neural crest-derived stem cellsNeural crest stem cellsNeurosphereNF200, neurofilament 200NG2, neuron-glial antigen 2p75 neurotrophin receptorp75NTR, p75 neurotrophin receptorPBS, phosphate-buffered salinePDGF, platelet-derived growth factorRA, all-trans-retinoic acidTBS, Tris-buffered salineUA, umbilical arteryUC, umbilical cordUmbilical cordUV, umbilical veinvWF, von Willebrand factorWJ, Wharton's jellyα-MEM, alpha-modified minimum essential mediumβME, β-mercaptoethanol

Identifiers

PMID33426237
PMCPMC7773767
OpenAlexW3114792865

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.