Evidence map›Paper›PMID 33426225›Full record

ReviewRegenerative therapy2020

Dental pulp stem cells response on the nanotopography of scaffold to regenerate dentin-pulp complex tissue.

Rasda Diana, Retno Ardhani, Yulita Kristanti, Pribadi Santosa

Abstract readReview
In one paragraph

Review in Regenerative therapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Article
  3. Bilayer gelatin-methacryloyl scaffold for pulp inflammation suppression and dentin-like tissue regeneration.Journal of controlled release : official journal of the Controlled Release Society · 2026
    Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Rasda DianaDepartment of Conservative Dentistry, Faculty of Dentistry Universitas Gadjah Mada, Jl Denta Sekip Utara, Yogyakarta, 55281, Indonesia.
Retno ArdhaniDepartment of Dental Biomedical Sciences, Faculty of Dentistry Universitas Gadjah Mada, Jl Denta Sekip Utara, Yogyakarta, 55281, Indonesia.
Yulita KristantiDepartment of Conservative Dentistry, Faculty of Dentistry Universitas Gadjah Mada, Jl Denta Sekip Utara, Yogyakarta, 55281, Indonesia.
Pribadi SantosaDepartment of Conservative Dentistry, Faculty of Dentistry Universitas Gadjah Mada, Jl Denta Sekip Utara, Yogyakarta, 55281, Indonesia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The study of regenerative dentistry receives a fast growing interest. The potential ability of the dentin-pulp complex to regenerate is both promising and perplexing. To answer the challenging nature of the dental environment, scientists have developed various combinations of biomaterial scaffolds, stem cells, and incorporation of several growth factors. One of the crucial elements of this tissue engineering plan is the selection and fabrication of scaffolds. However, further findings suggest that cell behavior hugely depends on mechanical signaling. Nanotopography modifies scaffolds to alter cell migration and differentiation. However, to the best of the author's knowledge, there are very few studies addressing the correlation between nanotopography and dentin-pulp complex regeneration. Therefore, this article presents a comprehensive review of these studies and suggests a direction for future developments, particularly in the incorporation of nanotopography design for dentin-pulp complex regeneration.

Indexed as

BDNF, brain-derived neurotrophic factorBMP, bone morphogenetic proteinDental pulp stem cellDentin-pulp complex tissueDPSC, dental pulp stem cellECM, extracellular matrixFGF2, fibroblast growth factor-2GDNF, glial cell line-derived neurotrophic factorGelMA, methacrylated gelatinGO, graphene oxideIGF, insulin-like growth factorION-CPC, iron oxide nanoparticle-incorporating calcium phosphate cementLPS, lipopolysaccharideNanotopographyNGF, nerve growth factorPCL, polycaprolactonePDGF, platelet-derived growth factorPEGMA, poly(ethylene glycol) dimethacrylatePGA, polyglycolic acidPHMS, polyhydroxymethylsiloxanePLGA, poly-dl-lactic-co-glycolic acidPLLA, poly-l-lactic acidRegenerative dentistryRGO, reduced graphene oxideSACP, stem cells from apical papillaScaffoldSDF-1, stromal cell-derived factor-1SHED, stem cells from human exfoliated deciduous teethTGF-β, transforming growth factor-βTNF-α, t umour necrosis factor-alphaVEGF, vascular endothelial growth factor

Identifiers

PMID33426225
PMCPMC7770425

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.