ArticleRegenerative therapy2020
Three-dimensional spheroid culture of canine hepatocyte-like cells derived from bone marrow mesenchymal stem cells.
Article in Regenerative therapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 23 citations in OpenAlex.
- Development of rematuration of canine chemically induced hepatic progenitor cells using 3D rocking culture.Regenerative therapy · 2025Article
- Efficacy and safety of pseudolaric acid B againstFrontiers in medicine · 2025Article
- Reprogramming canine cryopreserved hepatocytes to hepatic progenitor cells using small molecule compounds.Regenerative therapy · 2024Article
- Establishment of large canine hepatocyte spheroids by mixing vascular endothelial cells and canine adipose-derived mesenchymal stem cells.Regenerative therapy · 2022Article
- The Application of Polycaprolactone Scaffolds with Poly(ε-caprolactone)-Poly(ethylene glycol)-Poly(ε-caprolactone) Loaded on Kidney Cell Culture.Materials (Basel, Switzerland) · 2022Article
- In vitro and in vivo efficacy of thiacloprid against Echinococcus multilocularis.Parasites & vectors · 2021Article
- In vivo and in vitro efficacy of crocin against Echinococcus multilocularis.Parasites & vectors · 2021Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionPrimary cultured hepatocytes are an important model for early safety evaluations of newly developed drugs. Many factors, however, hinder the wider applications of this technology, especially the difficulty to maintain these cells in long-term culture. To date, creating a stable supply of human or animal hepatocytes with proper hepatic function
methodsThe iHep cells were prepared by introducing two genes, namely, the Forkhead box A1 (
resultsNotably, albumin was observed in the iHep spheroids and the expression of hepatic genes, such as albumin and drug metabolism
conclusionsUpon incorporating three-dimensional technology, we managed to achieve iHep spheroids that are closer in gene expression to living liver tissue compared to conventional monolayer cultures. Thus, we are one step closer to creating a sustainable
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.