ArticleJournal of immunology research2020
Gender Differences in Rheumatoid Arthritis: Interleukin-4 Plays an Important Role.
Article in Journal of immunology research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 30 citations in OpenAlex.
- Synergistic effects of ambient particulate matter and extreme weather events on arthritis risk: a prospective cohort study.BMC public health · 2026Article
- Article
- Interleukin-4 and clinical activity in rheumatoid arthritis: a sex-based analysis.Advances in rheumatology (London, England) · 2025Article
- Impact of vitamin D supplementation on disease activity and pain management in rheumatoid arthritis: a randomized double-blinded controlled study.BMC rheumatology · 2025Article
- Association Between Biologics and Janus Kinase Inhibitors With Inflammatory Bowel Disease as Paradoxical Reactions: A Real-World Assessment.United European gastroenterology journal · 2025Article
- Effect of acute exercise on gene expression in peripheral blood mononuclear cells of puberty children.Scientific reports · 2024Article
- Immune dynamics throughout life in relation to sex hormones and perspectives gained from gender-affirming hormone therapy.Frontiers in immunology · 2024Review
- Tailoring Rheumatoid Arthritis Treatment through a Sex and Gender Lens.Journal of clinical medicine · 2023Review
- Alterations of the intestinal microbiome and metabolome in women with rheumatoid arthritis.Clinical and experimental medicine · 2023Article
- A Brief Overview: Sex Differences in Prevalent Chronic Musculoskeletal Conditions.International journal of environmental research and public health · 2023Article
- Genotyping of Patients with Adverse Drug Reaction or Therapy Failure: Database Analysis of a Pharmacogenetics Case Series Study.Pharmacogenomics and personalized medicine · 2023Article
- Short Peptides of Innate Immunity Protein Tag7 Inhibit the Production of Cytokines in CFA-Induced Arthritis.International journal of molecular sciences · 2022Article
- Sex, Allergic Diseases and Omalizumab.Biomedicines · 2022Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionRheumatoid arthritis (RA) is a chronic inflammatory disease characterized by symmetrical peripheral polyarthritis. A large number of studies have shown that RA is characterized by gender differences in clinical manifestations. The purpose of this study is to identify the key molecules of gender differences in patients with RA and to provide new molecular targets for personalized therapy.
results1230 DEGs were screened between RA and No-RA groups, and 306 DEGs were screened between male and female RA groups. The common key gene of the two groups is IL-4. Between RA group and No-RA group, interleukin-4 (IL-4) participates in cytokine-cytokine receptor interaction, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, etc.
conclusionThis study contributes to the molecular biological mechanism of gender differences in RA. IL-4 may have played an important role.
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