Evidence map›Paper›PMID 33425924›Full record

ReviewFrontiers in cell and developmental biology2020

Regulation of Mitochondrial Quality Control by Natural Drugs in the Treatment of Cardiovascular Diseases: Potential and Advantages.

Xing Chang, Wenjin Zhang, Zhenyu Zhao, Chunxia Ma, Tian Zhang, Qingyan Meng, Peizheng Yan, Lei Zhang, Yuping Zhao

RetractedOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in cell and developmental biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.

  1. Pooled it
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  12. Effect of thymoquinone on sepsis-induced cardiac damageThe Journal of international medical research · 2022
    Article
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  14. Fermentation ofNutrients · 2022
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Xing ChangChina Academy of Chinese Medical Sciences, Beijing, China.
Wenjin ZhangChina Academy of Chinese Medical Sciences, Beijing, China.
Zhenyu ZhaoChina Academy of Chinese Medical Sciences, Beijing, China.
Chunxia MaShandong Analysis and Test Center, Qilu University of Technology, Jinan, China.
Tian ZhangShandong University of Traditional Chinese Medicine, Jinan, China.
Qingyan MengShandong University of Traditional Chinese Medicine, Jinan, China.
Peizheng YanShandong University of Traditional Chinese Medicine, Jinan, China.
Lei ZhangJiangxi University of Traditional Chinese Medicine, Nanchang, China.
Yuping ZhaoChina Academy of Chinese Medical Sciences, Beijing, China.
Chinese Academy of Medical Sciences & Peking Union Medical College · CNShandong University of Traditional Chinese Medicine · CNGuang’anmen Hospital · CNJiangxi University of Traditional Chinese Medicine · CNQilu University of Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mitochondria are double-membraned cellular organelles that provide the required energy and metabolic intermediates to cardiomyocytes. Mitochondrial respiratory chain defects, structure abnormalities, and DNA mutations can affect the normal function of cardiomyocytes, causing an imbalance in intracellular calcium ion homeostasis, production of reactive oxygen species, and apoptosis. Mitochondrial quality control (MQC) is an important process that maintains mitochondrial homeostasis in cardiomyocytes and involves multi-level regulatory mechanisms, such as mitophagy, mitochondrial fission and fusion, mitochondrial energy metabolism, mitochondrial antioxidant system, and mitochondrial respiratory chain. Furthermore, MQC plays a role in the pathological mechanisms of various cardiovascular diseases (CVDs). In recent years, the regulatory effects of natural plants, drugs, and active ingredients on MQC in the context of CVDs have received significant attention. Effective active ingredients in natural drugs can influence the production of energy-supplying substances in the mitochondria, interfere with the expression of genes associated with mitochondrial energy requirements, and regulate various mechanisms of MQC modulation. Thus, these ingredients have therapeutic effects against CVDs. This review provides useful information about novel treatment options for CVDs and development of novel drugs targeting MQC.

Indexed as

cardiovascular diseaseseffective active ingredientsmitochondrial quality controlnatural drugsoxidative stressreactive oxygen species

Identifiers

PMID33425924
PMCPMC7793684
OpenAlexW3116377134

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.