Evidence map›Paper›PMID 33425896›Full record

ArticleFrontiers in cell and developmental biology2020

Regeneration of Functional Neurons After Spinal Cord Injury via

Brendan Puls, Yan Ding, Fengyu Zhang, Mengjie Pan, Zhuofan Lei, Zifei Pei, Mei Jiang, Yuting Bai, Cody Forsyth, Morgan Metzger and 10 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cell and developmental biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
85citing papers in PubMed, 1 pooled it
6.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

85 citing papers in PubMed, 1 synthesis or guideline pooled it, 119 citations in OpenAlex.

  1. Pooled it
  2. Article
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  4. Article
  5. Article
  6. Article
  7. Article
  8. Transcriptomics Insights into Spinal Cord Injury for Therapy Development.International journal of molecular sciences · 2026
    Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Biomaterials and cell-based therapy post spinal cord injury.Journal of translational medicine · 2025
    Review
  19. Review
  20. Review

25 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 3 institutions in 2 countries.

Brendan PulsDepartment of Biology, Huck Institutes of Life Sciences, The Pennsylvania State University, University Park, PA, United States.
Yan DingDepartment of Biology, Huck Institutes of Life Sciences, The Pennsylvania State University, University Park, PA, United States.
Fengyu ZhangDepartment of Biology, Huck Institutes of Life Sciences, The Pennsylvania State University, University Park, PA, United States.
Mengjie PanDepartment of Biology, Huck Institutes of Life Sciences, The Pennsylvania State University, University Park, PA, United States.
Zhuofan LeiDepartment of Biology, Huck Institutes of Life Sciences, The Pennsylvania State University, University Park, PA, United States.
Zifei PeiDepartment of Biology, Huck Institutes of Life Sciences, The Pennsylvania State University, University Park, PA, United States.
Mei JiangDepartment of Biology, Huck Institutes of Life Sciences, The Pennsylvania State University, University Park, PA, United States.
Yuting BaiDepartment of Biology, Huck Institutes of Life Sciences, The Pennsylvania State University, University Park, PA, United States.
Cody ForsythDepartment of Biology, Huck Institutes of Life Sciences, The Pennsylvania State University, University Park, PA, United States.
Morgan MetzgerDepartment of Biology, Huck Institutes of Life Sciences, The Pennsylvania State University, University Park, PA, United States.
Tanvi RanaDepartment of Biology, Huck Institutes of Life Sciences, The Pennsylvania State University, University Park, PA, United States.
Lei ZhangDepartment of Biology, Huck Institutes of Life Sciences, The Pennsylvania State University, University Park, PA, United States.
Xiaoyun DingDepartment of Biology, Huck Institutes of Life Sciences, The Pennsylvania State University, University Park, PA, United States.
Matthew KeefeDepartment of Biology, Huck Institutes of Life Sciences, The Pennsylvania State University, University Park, PA, United States.
Alice CaiDepartment of Biology, Huck Institutes of Life Sciences, The Pennsylvania State University, University Park, PA, United States.
Austin RedillaDepartment of Biology, Huck Institutes of Life Sciences, The Pennsylvania State University, University Park, PA, United States.
Michael LaiDepartment of Biology, Huck Institutes of Life Sciences, The Pennsylvania State University, University Park, PA, United States.
Kevin HeDepartment of Biology, Huck Institutes of Life Sciences, The Pennsylvania State University, University Park, PA, United States.
Hedong LiDepartment of Biology, Huck Institutes of Life Sciences, The Pennsylvania State University, University Park, PA, United States.
Gong ChenDepartment of Biology, Huck Institutes of Life Sciences, The Pennsylvania State University, University Park, PA, United States.
Pennsylvania State University · USAugusta University · USJinan University · CN

Funding

In Vivo Reprogramming Reactive Astrocytes into Functional Neuorons by MicroRNA-124 in the Injured Spinal CordR21NS104394 · NINDS · PENNSYLVANIA STATE UNIVERSITY, THE · PI LI, HEDONG · 2018 to 2019
$440k
NINDS NIH HHS R21 NS104394
6 · The paper itself

Abstract

Spinal cord injury (SCI) often leads to impaired motor and sensory functions, partially because the injury-induced neuronal loss cannot be easily replenished through endogenous mechanisms.

Indexed as

astrocytein vivo reprogrammingNeuroD1neuronal conversionspinal cord

Identifiers

PMID33425896
PMCPMC7793709
OpenAlexW3113127439

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.