Evidence map›Paper›PMID 33425875›Full record

ArticleFrontiers in bioengineering and biotechnology2020

Study on Development of Composite Hydrogels With Tunable Structures and Properties for Tumor-on-a-Chip Research.

Zaozao Chen, Fei Wang, Jie Zhang, Xiaowei Sun, Yuchuan Yan, Yan Wang, Jun Ouyang, Jing Zhang, Tess Honore, Jianjun Ge and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in bioengineering and biotechnology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Review
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  5. Article
  6. Breaking the mold: 3D cell cultures reshaping the future of cancer research.Frontiers in cell and developmental biology · 2024
    Review
  7. Review
  8. Article
  9. Review
  10. Article
  11. Multicellular 3D Models to Study Tumour-Stroma Interactions.International journal of molecular sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Zaozao ChenState Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing, China.
Fei WangInstitute of Biomaterials and Medical Devices, Southeast University, Suzhou, China.
Jie ZhangInstitute of Biomaterials and Medical Devices, Southeast University, Suzhou, China.
Xiaowei SunInstitute of Biomaterials and Medical Devices, Southeast University, Suzhou, China.
Yuchuan YanInstitute of Biomaterials and Medical Devices, Southeast University, Suzhou, China.
Yan WangInstitute of Biomaterials and Medical Devices, Southeast University, Suzhou, China.
Jun OuyangInstitute of Biomaterials and Medical Devices, Southeast University, Suzhou, China.
Jing ZhangInstitute of Biomaterials and Medical Devices, Southeast University, Suzhou, China.
Tess HonoreState Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing, China.
Jianjun GeInstitute of Biomaterials and Medical Devices, Southeast University, Suzhou, China.
Zhongze GuState Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A major factor for developing new tumor models is to recreate a proper three-dimensional environment for 3D tumors culture. In this 3D microenvironment, extracellular matrices play important roles in regulation of hallmark features of cancer through biochemical and mechanical signals. The fabrication of a mechanical and biophysical controllable hydrogel, while sharing similarities with Matrigel in cancer invasiveness evaluation, is an urgent but unmet need. In this study, we developed a hybrid hydrogel system composed of GelMA and hydrolyzed collagen to model tumor micro-environment and tested with several cancer cells with different origin and characteristics. This hydrogel possesses a well-ordered homogenous microstructure, excellent permeability and an adjustable mechanical stiffness. This hydrogel demonstrated similar properties as Matrigel in tumor spheroids culture and 3D tumor invasiveness studies. It was further applied in a Tumor-on-a-Chip system with 3D-bioprinting. Our research demonstrated this hydrogel's effectiveness in tumor 3D culture, and its potential to replace Matrigel in cancer invasiveness evaluation.

Indexed as

3D-ECMbio-printingcancer invasivenesshydrogelmicrochip

Identifiers

PMID33425875
PMCPMC7786431

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.