ArticleFrontiers in bioengineering and biotechnology2020
Colorimetric Nanoplasmonics to Spot Hyperglycemia From Saliva.
Article in Frontiers in bioengineering and biotechnology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- A Unified YOLOv8 Approach for Point-of-Care Diagnostics of SalivaryBiosensors · 2025Article
- A spectroscopy based prototype for the noninvasive detection of diabetes from human saliva using nanohybrids acting as nanozyme.Scientific reports · 2023Article
- Nanozymes based on octahedral platinum nanocrystals with {111} surface facets: glucose oxidase mimicking activity in electrochemical sensors.Mikrochimica acta · 2023Article
- Fabrication of an electrospun polycaprolactone substrate for colorimetric bioassays.Biomedical microdevices · 2023Article
- A dual-color plasmonic immunosensor for salivary cortisol measurement.Nanoscale advances · 2023Article
- Gold nanoparticle-based optical nanosensors for food and health safety monitoring: recent advances and future perspectives.RSC advances · 2022Review
- Nanoplasmonic Strip Test for Salivary Glucose Monitoring.Nanomaterials (Basel, Switzerland) · 2021Article
- Paper-Based Multiplexed Colorimetric Device for the Simultaneous Detection of Salivary Biomarkers.Biosensors · 2021Article
- Spiky Gold Nanoparticles for the Photothermal Eradication of Colon Cancer Cells.Nanomaterials (Basel, Switzerland) · 2021Article
- Nanosensors for Visual Detection of Glucose in Biofluids: Are We Ready for Instrument-Free Home-Testing?Materials (Basel, Switzerland) · 2021Review
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4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Early diagnostics and point-of-care (POC) devices can save people's lives or drastically improve their quality. In particular, millions of diabetic patients worldwide benefit from POC devices for frequent self-monitoring of blood glucose. Yet, this still involves invasive sampling processes, which are quite discomforting for frequent measurements, or implantable devices dedicated to selected chronic patients, thus precluding large-scale monitoring of the globally increasing diabetic disorders. Here, we report a non-invasive colorimetric sensing platform to identify hyperglycemia from saliva. We designed plasmonic multibranched gold nanostructures, able to rapidly change their shape and color (naked-eye detection) in the presence of hyperglycemic conditions. This "reshaping approach" provides a fast visual response and high sensitivity, overcoming common detection issues related to signal (color intensity) losses and bio-matrix interferences. Notably, optimal performances of the assay were achieved in real biological samples, where the biomolecular environment was found to play a key role. Finally, we developed a dipstick prototype as a rapid home-testing kit.
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