Evidence map›Paper›PMID 33425757›Full record

ArticleFrontiers in oncology2020

The Suppressing Effects of Dkk3 Expression on Aggressiveness and Tumorigenesis of Colorectal Cancer.

Shuang Zhao, Chang-Lai Hao, En-Hong Zhao, Hua-Mao Jiang, Hua-Chuan Zheng

Open access · goldAbstract read
In one paragraph

Article in Frontiers in oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Shuang ZhaoDepartment of Oncology and Experimental Center, The Affiliated Hospital of Chengde Medical University, Chengde, China.
Chang-Lai HaoDepartment of Hematology, The Affiliated Hospital of Chengde Medical University, Chengde, China.
En-Hong ZhaoDepartment of Surgery, The Affiliated Hospital of Chengde Medical University, Chengde, China.
Hua-Mao JiangDepartment of Urology, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, China.
Hua-Chuan ZhengDepartment of Oncology and Experimental Center, The Affiliated Hospital of Chengde Medical University, Chengde, China.
Chengde Medical University · CNJinzhou Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dkk3 has been discovered during comparison of immortalized and parental cells. Its expression has been shown to reduce colony formation and induce apoptosis of cancer cells, acting as a tumor suppressor. Herein, we demonstrate that Dkk3 overexpression or protein treatment may inhibit colorectal cancer cell proliferation, migration, and invasion and that they may promote apoptosis and G

Indexed as

aggressive phenotypescolorectal cancerDkk3pathological behaviorsprognosistumorigenesis

Identifiers

PMID33425757
PMCPMC7794014
OpenAlexW3106962204

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.