Evidence map›Paper›PMID 33425489›Full record

ArticleMolecular therapy. Nucleic acids2021

CircMEG3 inhibits telomerase activity by reducing Cbf5 in human liver cancer stem cells.

Xiaoxue Jiang, Libo Xing, Yingjie Chen, Rushi Qin, Shuting Song, Yanan Lu, Sijie Xie, Liyan Wang, Hu Pu, Xin Gui and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular therapy. Nucleic acids, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 42 citations in OpenAlex.

  1. Circular RNAs in ferroptosis regulation and tumor progression of gynecological and breast cancers: molecular mechanisms and therapeutic potential.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Review
  2. Review
  3. Circular RNAs: key regulators in cancer stem cell dynamics.Molecular genetics and genomics : MGG · 2026
    Review
  4. Review
  5. Review
  6. Review
  7. Review
  8. Review
  9. Review
  10. Review
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  14. mActa biochimica et biophysica Sinica · 2023
    Review
  15. Review
  16. Review
  17. CRISPR-based mFrontiers in cell and developmental biology · 2023
    Review
  18. Article
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  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 1 institution in 1 country.

Xiaoxue JiangShanghai Putuo District People's Hospital, School of Life Science and Technology, Tongji University, Shanghai 200092, China.
Libo XingShanghai Putuo District People's Hospital, School of Life Science and Technology, Tongji University, Shanghai 200092, China.
Yingjie ChenShanghai Putuo District People's Hospital, School of Life Science and Technology, Tongji University, Shanghai 200092, China.
Rushi QinShanghai Putuo District People's Hospital, School of Life Science and Technology, Tongji University, Shanghai 200092, China.
Shuting SongShanghai Putuo District People's Hospital, School of Life Science and Technology, Tongji University, Shanghai 200092, China.
Yanan LuShanghai Putuo District People's Hospital, School of Life Science and Technology, Tongji University, Shanghai 200092, China.
Sijie XieShanghai Putuo District People's Hospital, School of Life Science and Technology, Tongji University, Shanghai 200092, China.
Liyan WangShanghai Putuo District People's Hospital, School of Life Science and Technology, Tongji University, Shanghai 200092, China.
Hu PuShanghai Putuo District People's Hospital, School of Life Science and Technology, Tongji University, Shanghai 200092, China.
Xin GuiShanghai Putuo District People's Hospital, School of Life Science and Technology, Tongji University, Shanghai 200092, China.
Tianming LiShanghai Putuo District People's Hospital, School of Life Science and Technology, Tongji University, Shanghai 200092, China.
Jie XuSchool of Medicine, Tongji University, Shanghai 200092, China.
Jiao LiSchool of Medicine, Tongji University, Shanghai 200092, China.
Song JiaSchool of Medicine, Tongji University, Shanghai 200092, China.
Dongdong LuShanghai Putuo District People's Hospital, School of Life Science and Technology, Tongji University, Shanghai 200092, China.
Tongji University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Circular RNA (CircRNA) is a newly identified special class of non-coding RNA (ncRNA) that plays an important regulatory role in the progression of certain diseases. Herein, our results indicate that CircMEG3 is downregulated expression and negatively correlated with the expression of telomerase-related gene Cbf5 in human liver cancer. Moreover, CircMEG3 inhibits the growth of human liver cancer stem cells

Indexed as

Cbf5CircMEG3HULCliver cancer stem cellsMETTL3telomere

Identifiers

PMID33425489
PMCPMC7779543
OpenAlexW3105293768

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.