ArticleJournal of pharmaceutical analysis2020
Offline two-dimensional liquid chromatography coupled with ion mobility-quadrupole time-of-flight mass spectrometry enabling four-dimensional separation and characterization of the multicomponents from white ginseng and red ginseng.
Article in Journal of pharmaceutical analysis, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Configurational Isomer Differentiation Between 20(S)- and 20(R)-Ginsenosides in Red Ginseng via Applying [CuPhytochemical analysis : PCA · 2026Article
- Enhancing ginsenoside isomers annotation by integrated analysis of electron-activated dissociation and collision-induced dissociation tandem mass spectrometry.Journal of pharmaceutical analysis · 2026Article
- Spatial Profiling of Gingerol and Shogaol Analogues in IntactMolecules (Basel, Switzerland) · 2026Article
- Trace component fishing strategy based on offline two-dimensional liquid chromatography combined with PRDX3-surface plasmon resonance forJournal of pharmaceutical analysis · 2025Article
- Systematic quality control of Shi Jue Ming San by two-dimensional liquid chromatography/mass spectrometry and adjusted multiple reaction monitoring of quality markers.Analytical and bioanalytical chemistry · 2025Article
- Metabolomic Profiles and Differential Constituents ofMolecules (Basel, Switzerland) · 2025Article
- Rare ginsenosides: A unique perspective of ginseng research.Journal of advanced research · 2024Review
- Comprehensive Characterization of Triterpene Saponins in Rhizoma Panacis Japonici by Offline Two-Dimensional Liquid Chromatography Coupled to Quadrupole Time-of-Flight Mass Spectrometry.Molecules (Basel, Switzerland) · 2024Article
- Comprehensive metabolome characterization and comparison between two sources of Dragon's blood by integrating liquid chromatography/mass spectrometry and chemometrics.Analytical and bioanalytical chemistry · 2024Article
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- Collision Cross Section Prediction Based on Machine Learning.Molecules (Basel, Switzerland) · 2023Review
- Progress and prediction of multicomponent quantification in complex systems with practical LC-UV methods.Journal of pharmaceutical analysis · 2023Review
- Multicomponent Characterization of the Flower Bud ofMolecules (Basel, Switzerland) · 2022Article
- Integrating Enhanced Profiling and Chemometrics to Unveil the Potential Markers for Differentiating among the Leaves ofMolecules (Basel, Switzerland) · 2022Article
- Systematic Qualitative and Quantitative Analyses of Wenxin Granule via Ultra-High Performance Liquid Chromatography Coupled with Ion Mobility Quadrupole Time-of-Flight Mass Spectrometry and Triple Quadrupole-Linear Ion Trap Mass Spectrometry.Molecules (Basel, Switzerland) · 2022Article
- An Integrated Mutually Oriented "Chemical Profiling-Pharmaceutical Effect" Strategy for Screening Discriminating Markers of Underlying Hepatoprotective Effects to Distinguish Garden-Cultivated from Mountain-CultivatedMolecules (Basel, Switzerland) · 2021Article
- An integrated strategy of MS-network-based offline 2DLC-QTOF-MS/MS coupled with UHPLC-QTRAPAnalytical and bioanalytical chemistry · 2021Article
- Characterization of the Components and Pharmacological Effects of Mountain-Cultivated Ginseng and Garden Ginseng Based on the Integrative Pharmacology Strategy.Frontiers in pharmacology · 2021Article
- Hemophagocytic lymphohistiocytosis: a review inspired by the COVID-19 pandemic.Rheumatology international · 2021Review
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inherent complexity of plant metabolites necessitates the use of multi-dimensional information to accomplish comprehensive profiling and confirmative identification. A dimension-enhanced strategy, by offline two-dimensional liquid chromatography/ion mobility-quadrupole time-of-flight mass spectrometry (2D-LC/IM-QTOF-MS) enabling four-dimensional separations (2D-LC, IM, and MS), is proposed. In combination with in-house database-driven automated peak annotation, this strategy was utilized to characterize ginsenosides simultaneously from white ginseng (WG) and red ginseng (RG). An offline 2D-LC system configuring an Xbridge Amide column and an HSS T3 column showed orthogonality 0.76 in the resolution of ginsenosides. Ginsenoside analysis was performed by data-independent high-definition MS
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