ReviewJournal of pharmaceutical analysis2020
Challenges for cysteamine stabilization, quantification, and biological effects improvement.
Review in Journal of pharmaceutical analysis, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 97 citations in OpenAlex.
- Efficacy and safety of cysteamine 5% cream for the management of melasma: a systematic review and meta-analysis of randomized controlled trials.Archives of dermatological research · 2024Pooled it
- Early ADME and Preliminary Toxicity Studies of I-152, anChemical research in toxicology · 2026Article
- Effects of varying levels of coated cysteamine hydrochloride in diet on growth performance and carcass quality of steers.Animal bioscience · 2025Article
- Self-Assembled Cysteamine Reporter Ligands for SERS Nitrate Detection in Continuous Flow.Langmuir : the ACS journal of surfaces and colloids · 2025Article
- Synthetic Control of Water-Stable Hybrid Perovskitoid Semiconductors.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- Impact of root exudates on soil reconstruction and bacterial community resumption in open-pit coal mines.Frontiers in microbiology · 2025Article
- Article
- Harnessing Novel Reduced Graphene Oxide-Based Aerogel for Efficient Organic Contaminant and Heavy Metal Removal in Aqueous Environments.Nanomaterials (Basel, Switzerland) · 2024Article
- Article
- A New and Rapid LC-MS/MS Method for the Determination of Cysteamine Plasma Levels in Cystinosis Patients.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Colorimetric detection of oral bacteria using functionalized gold nanoparticles as a plasmonic biosensor array.Nanoscale advances · 2024Article
- Effects of sodium selenite, cysteamine, bacterially synthesized Se-NPs, and cysteamine loaded on Se-NPs on ram sperm cryopreservation.Scientific reports · 2024Article
- Cysteamine Eye Drops in Hyaluronic Acid Packaged in Innovative Single-Dose Systems, Part II: Long-Term Stability and Clinical Ocular Biopermanence.Pharmaceutics · 2023Article
- Toward Single Cell Tattoos: Biotransfer Printing of Lithographic Gold Nanopatterns on Live Cells.Nano letters · 2023Article
- Localized Surface Plasmon Resonance-Based Nanosensor for Rapid Detection of Glyphosate in Food Samples.Biosensors · 2023Article
- Article
- Effect of coated cysteamine hydrochloride and probiotics supplemented alone or in combination on feed intake, nutrients digestibility, ruminal fermentation, and blood metabolites of Kamphaeng Saen beef heifers.Tropical animal health and production · 2023Article
- Cysteamine improves growth and the GH/IGF axis in gilthead sea bream (Frontiers in endocrinology · 2023Article
- A Review on the Antimutagenic and Anticancer Effects of Cysteamine.Advances in pharmacological and pharmaceutical sciences · 2023Review
- A new proof of evidence of cysteamine quantification for therapeutic drug monitoring in patients with cystinosis.Orphanet journal of rare diseases · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aminothiol cysteamine, derived from coenzyme A degradation in mammalian cells, presents several biological applications. However, the bitter taste and sickening odor, chemical instability, hygroscopicity, and poor pharmacokinetic profile of cysteamine limit its efficacy. The use of encapsulation systems is a good methodology to overcome these undesirable properties and improve the pharmacokinetic behavior of cysteamine. Besides, the conjugation of cysteamine to the surface of nanoparticles is generally proposed to improve the intra-oral delivery of cyclodextrin-drug inclusion complexes, as well as to enhance the colorimetric detection of compounds by a gold nanoparticle aggregation method. On the other hand, the detection and quantification of cysteamine is a challenging mission due to the lack of a chromophore in its structure and its susceptibility to oxidation before or during the analysis. Derivatization agents are therefore applied for the quantification of this molecule. To our knowledge, the derivatization techniques and the encapsulation systems used for cysteamine delivery were not reviewed previously. Thus, this review aims to compile all the data on these methods as well as to provide an overview of the various biological applications of cysteamine focusing on its skin application.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.