Evidence map›Paper›PMID 33425435›Full record

ArticleImmune network2020

Interleukin-10-Producing B Cells Help Suppress Ovariectomy-Mediated Osteoporosis.

Yuhua Wang, Wei Zhang, Seong-Min Lim, Li Xu, Jun-O Jin

Open access · diamondAbstract read
In one paragraph

Article in Immune network, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 22 citations in OpenAlex.

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  8. Frontiers in immunology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Yuhua WangDepartment of Prosthodontics, Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology, Shanghai 200011, China.ORCID https://orcid.org/0000-0003-0161-1906
Wei ZhangShanghai Public Health Clinical Center, Shanghai Medical College, Fudan University, Shanghai 201508, China.ORCID https://orcid.org/0000-0002-9262-849X
Seong-Min LimDepartment of Medical Biotechnology, Yeungnam University, Gyeongsan 38541, Korea.ORCID https://orcid.org/0000-0002-6303-6612
Li XuShanghai Public Health Clinical Center, Shanghai Medical College, Fudan University, Shanghai 201508, China.ORCID https://orcid.org/0000-0002-7883-0448
Jun-O JinShanghai Public Health Clinical Center, Shanghai Medical College, Fudan University, Shanghai 201508, China.ORCID https://orcid.org/0000-0003-4216-8111
Shanghai Public Health Clinical Center · CNShanghai Jiao Tong University · CNYeungnam University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Osteoporosis is prevalent in elderly women and it may cause dental implant failure. In particular, estrogen deficiency in postmenopausal women leads to higher rates of osteoporosis prevalence. Immune cell-mediated effects involving the development of osteoporosis have been studied previously; however, the role of IL-10-producing regulatory B (B10) cells in osteoporosis is largely unclear. Here, we examined the role of B10 cells in osteoporosis. C57BL/6 mice were subjected to ovariectomy (OVX). Fifteen weeks after OVX surgery, the first molar of the right maxillary was extracted, and twenty-four weeks after OVX surgery, serous progression of osteoporosis was observed in the alveolar bone. Moreover, the proportion of CD19

Indexed as

Adoptive transferBreg cellsOsteoporosisOvariectomyTh17 cellsTreg cells

Identifiers

PMID33425435
PMCPMC7779870
OpenAlexW3116348570

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.