Evidence map›Paper›PMID 33425245›Full record

ReviewComputational and structural biotechnology journal2021

Emerging frontiers in human milk microbiome research and suggested primers for 16S rRNA gene analysis.

Lilian Lopez Leyva, Nicholas J B Brereton, Kristine G Koski

Open access · goldAbstract readReview
In one paragraph

Review in Computational and structural biotechnology journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 45 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Lilian Lopez LeyvaSchool of Human Nutrition, McGill University, Macdonald Stewart Building, 21111 Lakeshore Road, Ste-Anne de Bellevue, QC H9X 3V9, Canada.
Nicholas J B BreretonInstitut de Recherche en Biologie Végétale, Université de Montréal, 4101 Sherbrooke St E, Montreal, QC H1X 2B2, Canada.
Kristine G KoskiSchool of Human Nutrition, McGill University, Macdonald Stewart Building, 21111 Lakeshore Road, Ste-Anne de Bellevue, QC H9X 3V9, Canada.
McGill University · CAUniversité de Montréal · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human milk is the ideal food for infants due to its unique nutritional and immune properties, and more recently human milk has also been recognized as an important source of bacteria for infants. However, a substantial amount of fundamental human milk microbiome information remains unclear, such as the origin, composition and function of the community and its members. There is emerging evidence to suggest that the diversity and composition of the milk microbiome might differ between lactation stages, due to maternal factors and diet, agrarian and urban lifestyles, and geographical location. The evolution of the methods used for studying milk microbiota, transitioning from culture dependent-approaches to include culture-independent approaches, has had an impact on findings and, in particular, primer selection within 16S rRNA gene barcoding studies have led to discrepancies in observed microbiota communities. Here, the current state-of-the-art is reviewed and emerging frontiers essential to improving our understanding of the human milk microbiome are considered.

Indexed as

16S rRNA geneHuman MilkMicrobial barcodingMicrobiomeMicrobiotaPCR primers

Identifiers

PMID33425245
PMCPMC7770459
OpenAlexW3112161058

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.