Evidence map›Paper›PMID 33425033›Full record

ArticleBeilstein journal of organic chemistry2020

An atom-economical addition of methyl azaarenes with aromatic aldehydes via benzylic C(sp

Divya Rohini Yennamaneni, Vasu Amrutham, Krishna Sai Gajula, Rammurthy Banothu, Murali Boosa, Narender Nama

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Beilstein journal of organic chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Divya Rohini YennamaneniCatalysis and Fine Chemicals Division, CSIR-Indian Institute of Chemical Technology, Hyderabad, Telangana, 500 007, India.
Vasu AmruthamCatalysis and Fine Chemicals Division, CSIR-Indian Institute of Chemical Technology, Hyderabad, Telangana, 500 007, India.
Krishna Sai GajulaCatalysis and Fine Chemicals Division, CSIR-Indian Institute of Chemical Technology, Hyderabad, Telangana, 500 007, India.
Rammurthy BanothuCatalysis and Fine Chemicals Division, CSIR-Indian Institute of Chemical Technology, Hyderabad, Telangana, 500 007, India.
Murali BoosaCatalysis and Fine Chemicals Division, CSIR-Indian Institute of Chemical Technology, Hyderabad, Telangana, 500 007, India.
Narender NamaCatalysis and Fine Chemicals Division, CSIR-Indian Institute of Chemical Technology, Hyderabad, Telangana, 500 007, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A convenient practical approach for the synthesis of 2-(pyridin-2-yl)ethanols by direct benzylic addition of azaarenes and aldehydes under catalyst- and solvent-free conditions is reported. This reaction is metal-free, green, and was carried out in a facile operative environment without using any hazardous transition metal catalysts or any other coupling reagents. Different aromatic aldehydes and azaarenes were monitored, and the yields of the resulting products were moderate to excellent. We accomplished several azaarene derivatives under neat conditions through a highly atom-economical pathway. To evaluate the preparative potential of this process, gram-scale reactions were performed up to a 10 g scale.

Indexed as

aldehydesazaarenesbenzylic additiongreen chemistrysolvent-free conditions

Identifiers

PMID33425033
PMCPMC7770386

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.