Evidence map›Paper›PMID 33424855›Full record

ArticleFrontiers in immunology2020

A Synthetic Small Molecule F240B Decreases NLRP3 Inflammasome Activation by Autophagy Induction.

Chun-Hsien Wu, Chin Heng Gan, Lan-Hui Li, Jen-Che Chang, Shin-Tai Chen, Mridula P Menon, Shu-Meng Cheng, Shih-Ping Yang, Chen-Lung Ho, Oleg V Chernikov and 3 more

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Interaction Between Autophagy andFrontiers in cellular and infection microbiology · 2022
    Review
  8. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 8 institutions in 3 countries.

Chun-Hsien WuDivision of Cardiology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Chin Heng GanDepartment of Chemistry, National University of Singapore, Singapore, Singapore.
Lan-Hui LiDepartment of Laboratory Medicine, Linsen, Chinese Medicine and Kunming Branch, Taipei City Hospital, Taipei, Taiwan.
Jen-Che ChangDepartment of Biotechnology and Animal Science, National Ilan University, Ilan, Taiwan.
Shin-Tai ChenDepartment of Biotechnology and Animal Science, National Ilan University, Ilan, Taiwan.
Mridula P MenonDepartment of Biotechnology and Animal Science, National Ilan University, Ilan, Taiwan.
Shu-Meng ChengDivision of Cardiology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Shih-Ping YangDivision of Cardiology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Chen-Lung HoDivision of Wood Cellulose, Taiwan Forestry Research Institute, Taipei, Taiwan.
Oleg V ChernikovG.B. Elyakov Pacific Institute of Bioorganic Chemistry FEB RAS, Vladivostok, Russia.
Chi-Hung LinInstitute of Microbiology and Immunology, National Yang-Ming University, Taipei, Taiwan.
Yulin LamDepartment of Chemistry, National University of Singapore, Singapore, Singapore.
Kuo-Feng HuaDepartment of Pathology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
National Ilan University · TWNational University of Singapore · SGNational Yang Ming Chiao Tung University · TWTri-Service General Hospital · TWChina Medical University · TWNational Defense Medical Center · TWPacific Institute of Bioorganic Chemistry. GB Elyakova Far Eastern Branch of the Russian Academy of Sciences · RUTaiwan Forestry Research Institute · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Conjugated polyenes are a class of widely occurring natural products with various biological functions. We previously identified 4-hydroxy auxarconjugatin B (4-HAB) as anti-inflammatory agent with an IC

Indexed as

AnimalsAnti-Inflammatory AgentsAutophagyAutophagy-Related ProteinsCytokinesDisease Models, AnimalHumansInflammasomesInflammation MediatorsMacrophagesMaleMiceMice, Inbred C57BLMitochondriaNLR Family, Pyrin Domain-Containing 3 ProteinPeritonitisAnti-Inflammatory AgentsAutophagy-Related ProteinsCytokinesInflammasomesInflammation MediatorsNLR Family, Pyrin Domain-Containing 3 ProteinNLRP3 protein, humanNlrp3 protein, mouseUric Acidautophagyconjugated polyenesmitochondriaNLRP3 inflammasomeperitonitis

Identifiers

PMID33424855
PMCPMC7793731
OpenAlexW3117651561

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.