ArticleFrontiers in immunology2020
Environmental Factor-Mediated Transgenerational Inheritance of
Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Maternal Phthalate Exposure and Allergic Diseases in Children: A Meta-Analysis and Network Toxicology.International journal of molecular sciences · 2025Pooled it
- Multi-Dimensional Perspective of the Gene and Environmental Interaction in Asthma.Clinical reviews in allergy & immunology · 2026Review
- Research advances on epigenetic modifications in dendritic cells in allergic rhinitis.Frontiers in immunology · 2025Review
- Increased di-(2-ethylhexyl) phthalate exposure poses a differential risk for adult asthma clusters.Respiratory research · 2024Article
- Exposure to endocrine disrupting chemicals impacts immunological and metabolic status of women during pregnancy.Molecular and cellular endocrinology · 2023Article
- Prenatal DEHP exposure predicts neurological disorders via transgenerational epigenetics.Scientific reports · 2023Article
- Di(2-ethylhexyl) phthalate mediates IL-33 productionFrontiers in immunology · 2023Article
- A Review on Epigenetic Inheritance of Experiences in Humans.Biochemical genetics · 2022Review
- Prevalence and Risk Factors for Allergic Rhinitis in China: A Systematic Review and Meta-Analysis.Evidence-based complementary and alternative medicine : eCAM · 2022Review
- Insulin-like growth factor 2 receptor is a key immune-related gene that is correlated with a poor prognosis in patients with triple-negative breast cancer: A bioinformatics analysis.Frontiers in oncology · 2022Article
- Di-(2-ethylhexyl) Phthalate Promotes Allergic Lung Inflammation by Modulating CD8αFrontiers in immunology · 2022Article
- Airway Wall Remodeling in Childhood Asthma-A Personalized Perspective from Cell Type-Specific Biology.Journal of personalized medicine · 2021Review
- Corylin Ameliorates LPS-Induced Acute Lung Injury via Suppressing the MAPKs and IL-6/STAT3 Signaling Pathways.Pharmaceuticals (Basel, Switzerland) · 2021Article
- Phthalate Exposure Pattern in Breast Milk within a Six-Month Postpartum Time in Southern Taiwan.International journal of environmental research and public health · 2021Article
- Association of blood transfusion-related di-(2-ethylhexyl) phthalate exposure with gut microbiota alterations in preterm infants.Jornal de pediatriaArticle
Corrections and comments
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Authors and funding
13 authors at 8 institutions in 3 countries.
Funding
Abstract
The developmental origin of allergic diseases has been suggested, but the molecular basis remains enigmatic. Exposure to environmental factors, such as di-(2-ethylhexyl) phthalate (DEHP; a common plasticizer), is suggested to be associated with increased childhood allergic asthma, but the causal relationship and its underlying mechanism remain unknown. This study explored the transgenerational mechanism of DEHP on allergic asthma and dendritic cell (DC) homeostasis through epigenetic modification. In a murine model, ancestral exposure of C57BL/6 mice to low-dose DEHP led to trans-generational promoter hypomethylation of the
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.