Evidence map›Paper›PMID 33424833›Full record

ArticleFrontiers in immunology2020

Vi-Vaccinations Induce Heterogeneous Plasma Cell Responses That Associate With Protection From Typhoid Fever.

Deborah L Cross, Marije K Verheul, Michael D Leipold, Gerlinde Obermoser, Celina Jin, Elizabeth Jones, Joshua S Starr, Irina Mohorianu, Christoph J Blohmke, Holden T Maecker and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Review
  5. Typhoid fever.Nature reviews. Disease primers · 2023
    Review
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Deborah L CrossThe Oxford Vaccine Group, Department of Paediatrics, University of Oxford, and the NIHR Oxford Biomedical Research Centre, Oxford, United Kingdom.
Marije K VerheulThe Oxford Vaccine Group, Department of Paediatrics, University of Oxford, and the NIHR Oxford Biomedical Research Centre, Oxford, United Kingdom.
Michael D LeipoldThe Human Immune Monitoring Center, Institute for Immunity, Transplantation and Infection, Stanford School of Medicine, Stanford, CA, United States.
Gerlinde ObermoserThe Human Immune Monitoring Center, Institute for Immunity, Transplantation and Infection, Stanford School of Medicine, Stanford, CA, United States.
Celina JinThe Oxford Vaccine Group, Department of Paediatrics, University of Oxford, and the NIHR Oxford Biomedical Research Centre, Oxford, United Kingdom.
Elizabeth JonesThe Oxford Vaccine Group, Department of Paediatrics, University of Oxford, and the NIHR Oxford Biomedical Research Centre, Oxford, United Kingdom.
Joshua S StarrThe Oxford Vaccine Group, Department of Paediatrics, University of Oxford, and the NIHR Oxford Biomedical Research Centre, Oxford, United Kingdom.
Irina MohorianuThe Oxford Vaccine Group, Department of Paediatrics, University of Oxford, and the NIHR Oxford Biomedical Research Centre, Oxford, United Kingdom.
Christoph J BlohmkeThe Oxford Vaccine Group, Department of Paediatrics, University of Oxford, and the NIHR Oxford Biomedical Research Centre, Oxford, United Kingdom.
Holden T MaeckerThe Human Immune Monitoring Center, Institute for Immunity, Transplantation and Infection, Stanford School of Medicine, Stanford, CA, United States.
Giorgio NapolitaniMRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom.
Jennifer HillThe Oxford Vaccine Group, Department of Paediatrics, University of Oxford, and the NIHR Oxford Biomedical Research Centre, Oxford, United Kingdom.
Andrew J PollardThe Oxford Vaccine Group, Department of Paediatrics, University of Oxford, and the NIHR Oxford Biomedical Research Centre, Oxford, United Kingdom.
University of Oxford · GBOxford BioMedica (United Kingdom) · GBMRC Weatherall Institute of Molecular Medicine · GB

Funding

CyTOF Mass CytometerS10RR027582 · NCRR · STANFORD UNIVERSITY · PI NOLAN, GARRY P · 2010 to 2010
$500k
Department of HealthNCRR NIH HHS S10 RR027582
6 · The paper itself

Abstract

Vi-polysaccharide conjugate vaccines are efficacious against cases of typhoid fever; however, an absolute correlate of protection is not established. In this study, we investigated the leukocyte response to a Vi-tetanus toxoid conjugate vaccine (Vi-TT) in comparison with a plain polysaccharide vaccine (Vi-PS) in healthy adults subsequently challenged with

Indexed as

ADP-ribosyl Cyclase 1AdultB-LymphocytesEnzyme-Linked Immunospot AssayFlow CytometryHumansImmunoglobulin AImmunologic MemoryLymphocyte ActivationMembrane GlycoproteinsPlasma CellsPolysaccharides, BacterialSalmonella typhiTetanus ToxoidT Follicular Helper CellsTyphoid FeverADP-ribosyl Cyclase 1capsular polysaccharide, SalmonellaCD38 protein, humanImmunoglobulin AMembrane GlycoproteinsPolysaccharides, BacterialTetanus ToxoidTyphoid-Paratyphoid VaccinesVaccines, ConjugateCyTOFELISpot assaymass cytometrySalmonella Typhityphoid feverVi-conjugate vaccine

Identifiers

PMID33424833
PMCPMC7793947
OpenAlexW3109844115

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.