ArticleFrontiers in neurology2020
Neural Correlates of Cognitive Dysfunctions in Cervical Spondylotic Myelopathy Patients: A Resting-State fMRI Study.
Article in Frontiers in neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Beyond the aging spine - a systematic review of functional changes in the human brain in cervical spondylotic myelopathy.GeroScience · 2024Pooled it
- Brain MRI changes in degenerative cervical myelopathy: a systematic review.EBioMedicine · 2024Pooled it
- Abnormalities of brain structure and function in cervical spondylosis: a multi-modal voxel-based meta-analysis.Frontiers in neuroscience · 2024Pooled it
- Investigation of cerebellar structure and static and dynamic functional connectivity in cervical spondylotic myelopathy patients.Neuroradiology · 2026Article
- Increased cervical spinal cord signal intensity corresponds to specific cerebellar and cerebral functional changes in degenerative cervical myelopathy patients.Scientific reports · 2026Article
- Integrative multimodal framework combining undercarboxylated osteocalcin and medial prefrontal cortex morphometry for prediction of cognitive decline in osteoporosis: a machine learning study.Frontiers in neurology · 2026Article
- Altered brain network centrality in patients with cervical spondylotic myelopathy: insights from resting-state fMRI.Frontiers in neurology · 2025Article
- Sex-specific alterations in functional connectivity and network topology in patients with degenerative cervical myelopathy.Scientific reports · 2024Article
- Neurodegeneration within the rostral spinal cord is associated with brain gray matter volume atrophy in the early stage of cervical spondylotic myelopathy.Spinal cord · 2024Article
- Systematic investigation of cerebellar functional alterations and their association with surgical outcomes in patients with degenerative cervical myelopathy: a resting-state fMRI study.La Radiologia medica · 2024Article
- Resting-state functional magnetic resonance imaging indices are related to electrophysiological dysfunction in degenerative cervical myelopathy.Scientific reports · 2024Article
- Intra- and inter-network connectivity abnormalities associated with surgical outcomes in degenerative cervical myelopathy patients: a resting-state fMRI study.Frontiers in neurology · 2024Article
- Voxel- and tensor-based morphometry with machine learning techniques identifying characteristic brain impairment in patients with cervical spondylotic myelopathy.Frontiers in neurology · 2024Article
- Abnormal intrinsic brain functional network dynamics in patients with cervical spondylotic myelopathy.Cognitive neurodynamics · 2023Article
- Preoperative pain hypersensitivity is associated with axial pain after posterior cervical spinal surgeries in degenerative cervical myelopathy patients: a preliminary resting-state fMRI study.Insights into imaging · 2023Article
- Remodeling of the brain correlates with gait instability in cervical spondylotic myelopathy.Frontiers in neuroscience · 2023Article
- Functional MRI evidence for primary motor cortex plasticity contributes to the disease's severity and prognosis of cervical spondylotic myelopathy patients.European radiology · 2022Article
- Brain connectivity markers in degenerative cervical myelopathy patients with depression for predicting the prognosis following decompression surgery.Frontiers in neurology · 2022Article
- Brain Structural and Functional Dissociated Patterns in Degenerative Cervical Myelopathy: A Case-Controlled Retrospective Resting-State fMRI Study.Frontiers in neurology · 2022Article
- Dynamic and Static Amplitude of Low-Frequency Fluctuation Is a Potential Biomarker for Predicting Prognosis of Degenerative Cervical Myelopathy Patients: A Preliminary Resting-State fMRI Study.Frontiers in neurology · 2022Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cervical spondylotic myelopathy (CSM) is a common disease of the elderly that is characterized by gait instability, sensorimotor deficits, etc. Recurrent symptoms including memory loss, poor attention, etc. have also been reported in recent studies. However, these have been rarely investigated in CSM patients. To investigate the cognitive deficits and their correlation with brain functional alterations, we conducted resting-state fMRI (rs-fMRI) signal variability. This is a novel indicator in the neuroimaging field for assessing the regional neural activity in CSM patients. Further, to explore the network changes in patients, functional connectivity (FC) and graph theory analyses were performed. Compared with the controls, the signal variabilities were significantly lower in the widespread brain regions especially at the default mode network (DMN), visual network, and somatosensory network. The altered inferior parietal lobule signal variability positively correlated with the cognitive function level. Moreover, the FC and the global efficiency of DMN increased in patients with CSM and positively correlated with the cognitive function level. According to the study results, (1) the cervical spondylotic myelopathy patients exhibited regional neural impairments, which correlated with the severity of cognitive deficits in the DMN brain regions, and (2) the increased FC and global efficiency of DMN can compensate for the regional impairment.
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