ArticleFrontiers in psychiatry2020
Altered Local Gyrification Index and Corresponding Functional Connectivity in Medication Free Major Depressive Disorder.
Article in Frontiers in psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed.
- Causal relationships between somatic movement, brain structures, and mental well-being: A multi-stage Mendelian randomization study.Psychological medicine · 2026Article
- Classification of major depressive disorder using vertex-wise brain sulcal depth, curvature, and thickness with a deep and a shallow learning model.Molecular psychiatry · 2026Article
- Association between Cortical Gyrification and Major Depression: Clinical Correlates.Psychopathology · 2026Article
- Surface-Based Morphometry Analysis of the Cerebral Cortex in Patients With Probable Idiopathic Rapid Eye Movement Sleep Behavior Disorder.Brain and behavior · 2024Article
- Cortical morphological changes in multiple sclerosis patients: a study of cortical thickness, sulcal depth, and local gyrification index.Neuroradiology · 2023Article
- Cortical and subcortical grey matter correlates of psychopathic traits in a Japanese community sample of young adults: sex and configurations of factors' level matter!Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Unsupervised cross-domain functional MRI adaptation for automated major depressive disorder identification.Medical image analysis · 2023Article
- Cortical gyrification pattern of depression in Parkinson's disease: a neuroimaging marker for disease severity?Frontiers in aging neuroscience · 2023Article
- Gyrification patterns in first-episode, drug-naïve major depression: Associations with plasma levels of brain-derived neurotrophic factor and psychiatric symptoms.Frontiers in psychiatry · 2022Article
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7 authors.
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Abstract
A lot of previous studies have documented that major depressive disorder (MDD) is a developmental disorder. The cortical surface measure, local gyrification index (LGI), can well reflect the fetal and early postnatal neurodevelopmental processes. Thus, LGI may provide new insight for the neuropathology of MDD. The previous studies only focused on the surface structural abnormality, but how the structural abnormality lead to functional connectivity changes is unexplored. In this study, we investigated LGI and corresponding functional connectivity difference in 28 medication-free MDD patients. We found significantly decreased LGI in left lingual gyrus (LING) and right posterior superior temporal sulcus (bSTS), and the changed LGI in bSTS was negatively correlated with disease onset age and anxiety scores. The following functional connectivity analyses identified decreased functional connectivities between LING and right LING, precentral gyrus, and middle temporal gyrus. The decreased functional connectivities were correlated with disease duration, onset, and depression symptoms. Our findings revealed abnormal LGI in LING and bSTS indicating that the abnormal developmental of visual and social cognition related brain areas may be an early biomarker for depression.
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