ArticleFrontiers in neuroscience2020
Topological Abnormalities of Functional Brain Network in Early-Stage Parkinson's Disease Patients With Mild Cognitive Impairment.
Article in Frontiers in neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Imaging Cognitive Impairment and Impulse Control Disorders in Parkinson's Disease.Frontiers in neurology · 2021Pooled it
- Safety and efficacy outcomes after intranasal administration of neural stem cells in cerebral palsy: a randomized phase 1/2 controlled trial.Stem cell research & therapy · 2023Trial
- Dynamic functional connectivity variability may explain hypoxia-induced cognitive impairment at high-altitude.iScience · 2026Article
- Structural covariance network alterations across the spectrum of cognitive status in Parkinson's disease.Clinical parkinsonism & related disorders · 2026Review
- Frontal, temporal, cerebellar changes link to sepsis survivors' cognitive issues: A resting state functional magnetic resonance imaging study.World journal of psychiatry · 2025Article
- Investigation of symptom-specific functional connectivity patterns in Parkinson's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- Hot Topics and Frontiers of Resting-State fMRI in Parkinson's Disease: Research Trends and Paradigm Shifts From a Bibliometric Perspective.Parkinson's disease · 2025Review
- Fractional amplitude of low-frequency fluctuation alterations in patients with cervical spondylotic myelopathy: a resting-state fMRI study.Neuroradiology · 2024Article
- Electroacupuncture modulates abnormal brain connectivity after ischemia reperfusion injury in rats: A graph theory-based approach.Brain and behavior · 2024Article
- Mild cognitive impairment in Parkinson's disease: current view.Frontiers in cognition · 2024Review
- Interactions between functional networks in Parkinson's disease mild cognitive impairment.Scientific reports · 2023Article
- Behavioral, neural and ultrastructural alterations in a graded-dose 6-OHDA mouse model of early-stage Parkinson's disease.Scientific reports · 2023Article
- Topological disruption of high-order functional networks in cognitively preserved Parkinson's disease.CNS neuroscience & therapeutics · 2023Article
- [Research progress and application of transfer entropy algorithm].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2022Article
- Directed Brain Connectivity Identifies Widespread Functional Network Abnormalities in Parkinson's Disease.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Exploration on the Improvement of Cognitive Function and Inflammatory Response in Perimenopausal Patients with Mild Cognitive Impairment by Self-Prepared Ningshen Prescription.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Alterations in Large-Scale Intrinsic Connectivity Networks in the Parkinson's Disease-Associated Cognitive Impairment Continuum: A Systematic Review.Noro psikiyatri arsivi · 2022Review
- Abnormal Topological Network in Parkinson's Disease With Impulse Control Disorders: A Resting-State Functional Magnetic Resonance Imaging Study.Frontiers in neuroscience · 2021Article
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
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Abstract
Recent studies have demonstrated structural and functional alterations in Parkinson's disease (PD) with mild cognitive impairment (MCI). However, the topological patterns of functional brain networks in newly diagnosed PD patients with MCI are unclear so far. In this study, we used functional magnetic resonance imaging (fMRI) and graph theory approaches to explore the functional brain network in 45 PD patients with MCI (PD-MCI), 22 PD patients without MCI (PD-nMCI), and 18 healthy controls (HC). We found that the PD-MCI, PD-nMCI, and HC groups exhibited a small-world architecture in the functional brain network. However, early-stage PD-MCI patients had decreased clustering coefficient, increased characteristic path length, and changed nodal centrality in the default mode network (DMN), control network (CN), somatomotor network (SMN), and visual network (VN), which might contribute to factors for MCI symptoms in PD patients. Our results demonstrated that PD-MCI patients were associated with disrupted topological organization in the functional network, thus providing a topological network insight into the role of information exchange in the underlying development of MCI symptoms in PD patients.
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