Evidence map›Paper›PMID 33424457›Full record

ArticleCurrent anesthesiology reports2020

Insights into the Neurobiology of Craving in Opioid Use Disorder.

Lindsay M Lueptow, Elizabeth C Shashkova, Margaret G Miller, Christopher J Evans, Catherine M Cahill

Open access · greenAbstract read
In one paragraph

Article in Current anesthesiology reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.5field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. The Use of Oxytocin for the Treatment of Opioid Use Disorder.Current pain and headache reports · 2023
    Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Lindsay M LueptowDepartment of Psychiatry and Biobehavioral Sciences, Los Angeles, CA, 90095, USA.
Elizabeth C ShashkovaShirley and Stefan Hatos Center for Neuropharmacology, Los Angeles, CA, 90095, USA.
Margaret G MillerShirley and Stefan Hatos Center for Neuropharmacology, Los Angeles, CA, 90095, USA.
Christopher J EvansDepartment of Psychiatry and Biobehavioral Sciences, Los Angeles, CA, 90095, USA.
Catherine M CahillDepartment of Psychiatry and Biobehavioral Sciences, Los Angeles, CA, 90095, USA.
University of California, Los Angeles · USUniversity of Southern California · US

Funding

The Role of Striosome Neurons in Mediating Opiod RewardP50DA005010 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WALWYN, WENDY M · 1987 to 2021
$30.7M
UCLA Training Program in Translational Neuroscience of Drug Abuse (TNDA)T32DA024635 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LARA A. RAY, Kate M Wassum · 2008 to 2026
$6.2M
NIDA NIH HHS P50 DA005010NIDA NIH HHS T32 DA024635
6 · The paper itself

Abstract

purpose of reviewOpioids remain the most potent form of pain relief currently available, yet have a high abuse liability. Here we discuss underlying neurobiological changes in Opioid Use Disorder (OUD) that likely contribute to drug craving, which in turn drives continued drug use and relapse. RECENT

findingsCraving has emerged as a strong indicator in drug-seeking and relapse. Studies have demonstrated a number of allostatic changes in circuitry that facilitate learning of drug-stimuli relationships, thereby augmenting cue-triggered drug use and relapse. SUMMARY: This review will focus on key neurobiological changes in underlying circuitry observed during the initial and continued exposure to opioids that result in an increase in neural-reactivity to drug-related intrinsic and extrinsic drug cues, and to enhanced learning of drug-context correlations. This sensitized learning state may be an indication of the underlying framework that drives craving and ultimately, motivates increased salience of drug cues and drives drug-seeking.

Indexed as

Drug cravingIncentive sensitizationNegative affectNegative reinforcementOpioid Use DisorderStress

Identifiers

PMID33424457
PMCPMC7790122
OpenAlexW3090846638

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.