ArticleSaudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society2020
Hydrogel-based matrices for controlled drug delivery of etamsylate: Prediction of
Article in Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 24 citations in OpenAlex.
- Detecting the Physicochemical Transformations in Solid Drug Products Stored for Long Periods of Time-Insights into DSC Application.Molecules (Basel, Switzerland) · 2026Article
- Evaluation of the Effect of Formulation Composition and Physicochemical Properties of Omeprazole and Bisoprolol Hemifumarate on Electrospun Nanofibers Characteristics.Nanotechnology, science and applications · 2025Article
- Resveratrol-loaded invasome gel: A promising nanoformulation for treatment of skin cancer.Drug delivery and translational research · 2024Article
- Influence of physico-chemical properties of hydroxypropyl methylcellulose on quetiapine fumarate release from sustained release matrix tablets.BMC chemistry · 2024Article
- Design, Development andRecent advances in drug delivery and formulation · 2024Article
- Preparation, Characterization and Evaluation of Flavonolignan Silymarin Effervescent Floating Matrix Tablets for Enhanced Oral Bioavailability.Molecules (Basel, Switzerland) · 2023Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo design oral controlled release (CR) hydrogel matrix tablets of etamsylate using various hydrophilic polymers. Additionally, to predict plasma concentration-time profiles of etamsylate released from different CR matrices.
methodsCharacterization of the
resultsThe release of etamsylate from all matrices showed a deviation from Fickian transport mechanism except; F2 followed Case II release whereas, F9 and F11 obeyed Fickian diffusion. CR hydrogel based-matrices (F4 and F11) demonstrated the maximum drug retardation and satisfied the USP release limits. Concentration-time profiles of etamsylate were predicted successfully from the
conclusionThe designed (F2-F11) matrices had the capability to extend the plasma level of etamsylate for an adequate time. However, F4 and F11 were considered the most ideal formulations for once daily application of etamsylate. The prediction of
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