Evidence map›Paper›PMID 33424216›Full record

ArticleFederal practitioner : for the health care professionals of the VA, DoD, and PHS2020

The Effect of Radium-223 Therapy in Agent Orange-Related Prostate Carcinoma.

Andrew Liman, Rashmikant Shah, Vida Passero, Jocelyn Tan, Hema Rai, Laurie Harrold, Joyce Tokarsky, Agnes Liman, Vidhi Gupta, Kristina Gerszten

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Federal practitioner : for the health care professionals of the VA, DoD, and PHS, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Andrew Limanis Section Chief, Hematology/Oncology and is a Physician, Pathology and Laboratory Medicine, both at VA Central California Health Care System in Fresno. is Section Chief; , , and are Physicians; is a Nurse Practitioner, all in the Hematology/Oncology section at VA Pittsburgh Health Care System (VAPHCS) in Pennsylvania. , , and are Physicians in the Radiology and Radiation Oncology section at VAPHCS. Andrew Liman is an Assistant Clinical Professor of Medicine at the University of California San Francisco at Fresno. Vida Passero, Laurie Harrold, Jocelyn Tan, and Hema Rai are Assistant Clinical Professors of Medicine at University of Pittsburgh Cancer Institute in Pennsylvania.
Rashmikant Shahis Section Chief, Hematology/Oncology and is a Physician, Pathology and Laboratory Medicine, both at VA Central California Health Care System in Fresno. is Section Chief; , , and are Physicians; is a Nurse Practitioner, all in the Hematology/Oncology section at VA Pittsburgh Health Care System (VAPHCS) in Pennsylvania. , , and are Physicians in the Radiology and Radiation Oncology section at VAPHCS. Andrew Liman is an Assistant Clinical Professor of Medicine at the University of California San Francisco at Fresno. Vida Passero, Laurie Harrold, Jocelyn Tan, and Hema Rai are Assistant Clinical Professors of Medicine at University of Pittsburgh Cancer Institute in Pennsylvania.
Vida Passerois Section Chief, Hematology/Oncology and is a Physician, Pathology and Laboratory Medicine, both at VA Central California Health Care System in Fresno. is Section Chief; , , and are Physicians; is a Nurse Practitioner, all in the Hematology/Oncology section at VA Pittsburgh Health Care System (VAPHCS) in Pennsylvania. , , and are Physicians in the Radiology and Radiation Oncology section at VAPHCS. Andrew Liman is an Assistant Clinical Professor of Medicine at the University of California San Francisco at Fresno. Vida Passero, Laurie Harrold, Jocelyn Tan, and Hema Rai are Assistant Clinical Professors of Medicine at University of Pittsburgh Cancer Institute in Pennsylvania.
Jocelyn Tanis Section Chief, Hematology/Oncology and is a Physician, Pathology and Laboratory Medicine, both at VA Central California Health Care System in Fresno. is Section Chief; , , and are Physicians; is a Nurse Practitioner, all in the Hematology/Oncology section at VA Pittsburgh Health Care System (VAPHCS) in Pennsylvania. , , and are Physicians in the Radiology and Radiation Oncology section at VAPHCS. Andrew Liman is an Assistant Clinical Professor of Medicine at the University of California San Francisco at Fresno. Vida Passero, Laurie Harrold, Jocelyn Tan, and Hema Rai are Assistant Clinical Professors of Medicine at University of Pittsburgh Cancer Institute in Pennsylvania.
Hema Raiis Section Chief, Hematology/Oncology and is a Physician, Pathology and Laboratory Medicine, both at VA Central California Health Care System in Fresno. is Section Chief; , , and are Physicians; is a Nurse Practitioner, all in the Hematology/Oncology section at VA Pittsburgh Health Care System (VAPHCS) in Pennsylvania. , , and are Physicians in the Radiology and Radiation Oncology section at VAPHCS. Andrew Liman is an Assistant Clinical Professor of Medicine at the University of California San Francisco at Fresno. Vida Passero, Laurie Harrold, Jocelyn Tan, and Hema Rai are Assistant Clinical Professors of Medicine at University of Pittsburgh Cancer Institute in Pennsylvania.
Laurie Harroldis Section Chief, Hematology/Oncology and is a Physician, Pathology and Laboratory Medicine, both at VA Central California Health Care System in Fresno. is Section Chief; , , and are Physicians; is a Nurse Practitioner, all in the Hematology/Oncology section at VA Pittsburgh Health Care System (VAPHCS) in Pennsylvania. , , and are Physicians in the Radiology and Radiation Oncology section at VAPHCS. Andrew Liman is an Assistant Clinical Professor of Medicine at the University of California San Francisco at Fresno. Vida Passero, Laurie Harrold, Jocelyn Tan, and Hema Rai are Assistant Clinical Professors of Medicine at University of Pittsburgh Cancer Institute in Pennsylvania.
Joyce Tokarskyis Section Chief, Hematology/Oncology and is a Physician, Pathology and Laboratory Medicine, both at VA Central California Health Care System in Fresno. is Section Chief; , , and are Physicians; is a Nurse Practitioner, all in the Hematology/Oncology section at VA Pittsburgh Health Care System (VAPHCS) in Pennsylvania. , , and are Physicians in the Radiology and Radiation Oncology section at VAPHCS. Andrew Liman is an Assistant Clinical Professor of Medicine at the University of California San Francisco at Fresno. Vida Passero, Laurie Harrold, Jocelyn Tan, and Hema Rai are Assistant Clinical Professors of Medicine at University of Pittsburgh Cancer Institute in Pennsylvania.
Agnes Limanis Section Chief, Hematology/Oncology and is a Physician, Pathology and Laboratory Medicine, both at VA Central California Health Care System in Fresno. is Section Chief; , , and are Physicians; is a Nurse Practitioner, all in the Hematology/Oncology section at VA Pittsburgh Health Care System (VAPHCS) in Pennsylvania. , , and are Physicians in the Radiology and Radiation Oncology section at VAPHCS. Andrew Liman is an Assistant Clinical Professor of Medicine at the University of California San Francisco at Fresno. Vida Passero, Laurie Harrold, Jocelyn Tan, and Hema Rai are Assistant Clinical Professors of Medicine at University of Pittsburgh Cancer Institute in Pennsylvania.
Vidhi Guptais Section Chief, Hematology/Oncology and is a Physician, Pathology and Laboratory Medicine, both at VA Central California Health Care System in Fresno. is Section Chief; , , and are Physicians; is a Nurse Practitioner, all in the Hematology/Oncology section at VA Pittsburgh Health Care System (VAPHCS) in Pennsylvania. , , and are Physicians in the Radiology and Radiation Oncology section at VAPHCS. Andrew Liman is an Assistant Clinical Professor of Medicine at the University of California San Francisco at Fresno. Vida Passero, Laurie Harrold, Jocelyn Tan, and Hema Rai are Assistant Clinical Professors of Medicine at University of Pittsburgh Cancer Institute in Pennsylvania.
Kristina Gersztenis Section Chief, Hematology/Oncology and is a Physician, Pathology and Laboratory Medicine, both at VA Central California Health Care System in Fresno. is Section Chief; , , and are Physicians; is a Nurse Practitioner, all in the Hematology/Oncology section at VA Pittsburgh Health Care System (VAPHCS) in Pennsylvania. , , and are Physicians in the Radiology and Radiation Oncology section at VAPHCS. Andrew Liman is an Assistant Clinical Professor of Medicine at the University of California San Francisco at Fresno. Vida Passero, Laurie Harrold, Jocelyn Tan, and Hema Rai are Assistant Clinical Professors of Medicine at University of Pittsburgh Cancer Institute in Pennsylvania.
VA Central California Health Care System · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRadium-223 (Ra-223) radioisotope has been reported to increase median survival in bone metastatic prostate carcinoma. The addition of Ra-223 to abiraterone was associated with an increased risk of bone fractures. There has been no comprehensive data for using Ra-223 in veterans who were exposed to Agent Orange (AO+).

methodsWe present a retrospective study of veterans with bone metastatic castration-resistant prostate cancer (CRPC) who received standard doses of Ra-223 and other sequential therapies at US Department of Veterans Affairs Pittsburgh Healthcare System in Pennsylvania from January 2014 to January 2019. Veterans were divided into 2 groups: those who were exposed to Agent Orange (AO+) and those who had no exposure (AO-). Time to study was calculated from the initiation of Ra-223. Time to skeletal-related events (SRE), progression of prostate specific antigen (PSA), bone metastasis, and alkaline phosphatase (ALP) were calculated in months using unpaired t test with 2-tailed

resultsThere were 34 veterans with bone metastatic CRPC: 17 veterans (50%) were AO+ and 17 veterans (50%) were AO-. The mean age of diagnosis of AO+ veterans was 62 years and 69 years (

conclusionsThere was no statistical difference between AO+ and AO- veterans in terms of time to SRE, PSA, bone and ALP progression, even though there was a trend of shorter duration in AO+ veterans. There was no median survival difference between Ra-223 first vs Ra-223 later as well as between AO+ and AO- but there is a trend of worse survival in AO+ veterans.

Identifiers

PMID33424216
PMCPMC7789849
OpenAlexW3108618433

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.