ArticleApplied physics. A, Materials science & processing2021
Marine biomimetics: bromotyrosines loaded chitinous skeleton as source of antibacterial agents.
Article in Applied physics. A, Materials science & processing, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 21 citations in OpenAlex.
- Extreme Biomimetics: Achievements and Fundamental Challenges for the Future.Biomimetics (Basel, Switzerland) · 2026Review
- 3D Skeletal Scaffolds of Marine Keratosan Demosponges Origin as Renewable Sources for Bioinspiration in Modern Structural Biomimetics and Tissue Engineering.Biomimetics (Basel, Switzerland) · 2026Review
- On the Mechanical Properties of Microfibre-Based 3D Chitinous Scaffolds from Selected Verongiida Sponges.Marine drugs · 2023Article
- The Loss of Structural Integrity of 3D Chitin Scaffolds fromMarine drugs · 2023Article
- Biomaterials from the sea: Future building blocks for biomedical applications.Bioactive materials · 2021Review
- Calcite Nanotuned Chitinous Skeletons of GiantInternational journal of molecular sciences · 2021Article
- The Anti-Viral Applications of Marine Resources for COVID-19 Treatment: An Overview.Marine drugs · 2021Review
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Authors and funding
9 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The marine sponges of the order Verongiida (Demospongiae: Porifera) have survived on our planet for more than 500 million years due to the presence of a unique strategy of chemical protection by biosynthesis of more than 300 derivatives of biologically active bromotyrosines as secondary metabolites. These compounds are synthesized within spherulocytes, highly specialized cells located within chitinous skeletal fibers of these sponges from where they can be extruded in the sea water and form protective space against pathogenic viruses, bacteria and other predators. This chitin is an example of unique biomaterial as source of substances with antibiotic properties. Traditionally, the attention of researchers was exclusively drawn to lipophilic bromotyrosines, the extraction methods of which were based on the use of organic solvents only. Alternatively, we have used in this work a biomimetic water-based approach, because in natural conditions, sponges actively extrude bromotyrosines that are miscible with the watery environment. This allowed us to isolate 3,5-dibromoquinolacetic acid from an aqueous extract of the dried demosponge SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00339-020-04167-0.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.