Evidence map›Paper›PMID 33423916›Full record

ArticleThe International journal on drug policy2021

Restrictive opioid prescribing policies and evolving risk environments: A qualitative study of the perspectives of patients who experienced an accidental opioid overdose.

Shane R Mueller, Jason M Glanz, Anh P Nguyen, Melanie Stowell, Stephen Koester, Deborah J Rinehart, Ingrid A Binswanger

Open access · greenAbstract read
In one paragraph

Article in The International journal on drug policy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.9field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 20 citations in OpenAlex.

  1. Palliative care development as a solution to mitigate the human crisis of cancer in low- and middle-income countries: a theory of change approach.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
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  11. Psychological Treatment for Chronic Pain: Improving Access and Integration.Psychological science in the public interest : a journal of the American Psychological Society · 2021
    Article
  12. Article
  13. Depoliticization of Violence: Critical Limits of Risk Environment Frameworks in Drug Use Research.Inquiry : a journal of medical care organization, provision and financing
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Shane R MuellerInstitute for Health Research, Kaiser Permanente Colorado, P.O. Box 378066, Denver, CO 80237, USA. Electronic address: Shane.Mueller@kp.org.
Jason M GlanzInstitute for Health Research, Kaiser Permanente Colorado, P.O. Box 378066, Denver, CO 80237, USA; Department of Epidemiology, Colorado School of Public Health, 13001 E 17th Place, Mail Stop B-119, Aurora CO 80045, United States.
Anh P NguyenInstitute for Health Research, Kaiser Permanente Colorado, P.O. Box 378066, Denver, CO 80237, USA.
Melanie StowellCenter for Health Systems Research, Office of Research, Denver Health and Hospital Authority, 777 Bannock St, MC 6551 Denver, Colorado 80204, United States.
Stephen KoesterAnthropology, Health & Behavioral Sciences, University of Colorado Denver, 777 Lawrence St, Denver, CO 80204, United States.
Deborah J RinehartCenter for Health Systems Research, Office of Research, Denver Health and Hospital Authority, 777 Bannock St, MC 6551 Denver, Colorado 80204, United States; Division of General Internal Medicine, University of Colorado School of Medicine, 13001 E 17th Place, Aurora CO 80045, United States.
Ingrid A BinswangerInstitute for Health Research, Kaiser Permanente Colorado, P.O. Box 378066, Denver, CO 80237, USA; Division of General Internal Medicine, University of Colorado School of Medicine, 13001 E 17th Place, Aurora CO 80045, United States; Colorado Permanente Medical Group, 10350 E. Dakota Ave, Denver CO 80247, United States.
Kaiser Permanente · USUniversity of Colorado Denver · USColorado School of Public Health · USDenver Health Medical Center · US

Funding

The Safety and Impact of Expanded Access to Naloxone in Health SystemsR01DA042059 · NIDA · KAISER FOUNDATION RESEARCH INSTITUTE · PI BINSWANGER, INGRID A, GLANZ, JASON M · 2016 to 2020
$3.6M
NIDA NIH HHS R01 DA042059
6 · The paper itself

Abstract

backgroundDespite policy efforts to prevent overdose, accidental overdoses among individuals prescribed opioids continue to occur. Guided by Rhodes' Risk Environment Framework, we examined the unintended consequences of restrictive policies by identifying macro policy and micro-level contextual factors that patients prescribed opioids for pain identified as contributing to overdose events.

methodsSemi-structured interviews were conducted with 31 patients prescribed opioids who experienced an accidental opioid overdose between April 2017 and June 2019 in two health systems.

resultsWe identified three interrelated factors that emerged within an evolving risk environment and may have increased patients' vulnerability for an accidental opioid overdose: desperation from persistent pain and comorbidities; limited knowledge about opioid medication safety and effectiveness; and restrictive opioid prescribing policies that exacerbated stigma, fear and mistrust and prevented open patient-clinician communication. When experiencing persistent pain, patients took matters into their own hands by taking more medications or in different intervals than prescribed, mixing them with other substances, or using illicitly obtained opioids.

conclusionFor some patients, macro-level policies and guidelines designed to reduce opioid overdoses by restricting opioid supply may have paradoxically created a micro-level risk environment that contributed to overdose events in a subset of patients.

Indexed as

Drug OverdoseOpiate OverdoseAnalgesics, OpioidHumansPolicyPractice Patterns, Physicians'Analgesics, OpioidOpioid overdoseOpioid taperingPolicyQualitativeRisk environment

Identifiers

PMID33423916
PMCPMC9134796
OpenAlexW3119540740

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.